Biocompatible coatings with high albumin affinity

C. C. Tsai, H. H. Huo, P. Kulkarni, R. C. Eberhart

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A process was developed to coat complex medical devices with a thin, transparent, biocompatible film. The film is based on silicone rubber (SR) but has higher albumin affinity than SR. Two polymer forms have been developed: one substitutes hydroxyl groups (OH), the other, 16 carbon acyl groups (C16) in the siloxane side chains. Oxymercuration/demercuration or hydroboration reactions can be used. SEM reveals film surfaces are smooth, uniform, and featureless. ATR/FTIR spectra and advancing/receding water contact angle measurements confirm the presence of surface OH groups and suggest the presence of surface acyl groups. Albumin adsorption and retention are markedly enhanced for surface OH and C16 concentrations as low as 5% reaction yield. Kinetics, isotherm, and competitive albumin/fibrinogen adsorption studies suggest that surface hydroxylation, and perhaps C16 acylation as well, markedly improve the albumin affinity, but not the fibrinogen affinity, of this material. The SR film can be durably coated on several materials, making it possible to favorably treat many blood-contacting devices, using a simple immersion process.

Original languageEnglish (US)
JournalASAIO Transactions
Volume36
Issue number3
StatePublished - Jul 1990

Fingerprint

Silicone Elastomers
Albumins
Coatings
Silicones
Fibrinogen
Adsorption
Siloxanes
Rubber
Rubber films
Equipment and Supplies
Acylation
Immersion
Fourier Transform Infrared Spectroscopy
Hydroxylation
Hydroxyl Radical
Angle measurement
Polymers
Carbon
Contact angle
Isotherms

ASJC Scopus subject areas

  • Biophysics

Cite this

Tsai, C. C., Huo, H. H., Kulkarni, P., & Eberhart, R. C. (1990). Biocompatible coatings with high albumin affinity. ASAIO Transactions, 36(3).

Biocompatible coatings with high albumin affinity. / Tsai, C. C.; Huo, H. H.; Kulkarni, P.; Eberhart, R. C.

In: ASAIO Transactions, Vol. 36, No. 3, 07.1990.

Research output: Contribution to journalArticle

Tsai, CC, Huo, HH, Kulkarni, P & Eberhart, RC 1990, 'Biocompatible coatings with high albumin affinity', ASAIO Transactions, vol. 36, no. 3.
Tsai CC, Huo HH, Kulkarni P, Eberhart RC. Biocompatible coatings with high albumin affinity. ASAIO Transactions. 1990 Jul;36(3).
Tsai, C. C. ; Huo, H. H. ; Kulkarni, P. ; Eberhart, R. C. / Biocompatible coatings with high albumin affinity. In: ASAIO Transactions. 1990 ; Vol. 36, No. 3.
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