Biologic response modifier OK-432 pretreatment reduces mortality in burned mice infected with gram-negative bacteria

I. A. Holder, R. G. Miller, A. N. Neely

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

When compared with a control group, mice pretreated with the biologic response modifier OK-432 showed increased survival when burned and infected with several strains of Pseudomonas aeruginosa and a Klebsiella pneumoniae isolate. Quantitative microbial counts in the skin, liver, and kidneys of burned mice infected with Pseudomonas aeruginosa showed that although skin counts were not different between control groups pretreated or untreated with OK-432, liver and kidney counts were reduced significantly in the group pretreated with OK-432. We speculate from these results that OK-432 pretreatment may enhance survival by enhancing host clearance of microorganisms entering the circulation from the burn wound. Making mice granulocytopenic by cyclophosphamide treatment or macrophage- deficient/dysfunctional by carrageenan treatment nullified any survival advantage given by OK-432 pretreatment. These results supported our speculation and suggested that both of these cell types were important in the mechanisms of enhanced survival afforded by OK-432 pretreatment.

Original languageEnglish (US)
Pages (from-to)401-405
Number of pages5
JournalJournal of Burn Care and Rehabilitation
Volume14
Issue number4
StatePublished - 1993

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Picibanil
Gram-Negative Bacteria
Mortality
Pseudomonas aeruginosa
Kidney
Control Groups
Skin
Carrageenan
Liver
Klebsiella pneumoniae
Cyclophosphamide
Macrophages
Wounds and Injuries

ASJC Scopus subject areas

  • Emergency Medicine
  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)

Cite this

Biologic response modifier OK-432 pretreatment reduces mortality in burned mice infected with gram-negative bacteria. / Holder, I. A.; Miller, R. G.; Neely, A. N.

In: Journal of Burn Care and Rehabilitation, Vol. 14, No. 4, 1993, p. 401-405.

Research output: Contribution to journalArticle

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