TY - JOUR
T1 - Biological activity of 3-chloro-azetidin-2-one derivatives having interesting antiproliferative activity on human breast cancer cell lines
AU - Chimento, Adele
AU - Sala, Marina
AU - Gomez-Monterrey, Isabel M.
AU - Musella, Simona
AU - Bertamino, Alessia
AU - Caruso, Anna
AU - Sinicropi, Maria Stefania
AU - Sirianni, Rosa
AU - Puoci, Francesco
AU - Parisi, Ortensia Ilaria
AU - Campana, Carmela
AU - Martire, Emilia
AU - Novellino, Ettore
AU - Saturnino, Carmela
AU - Campiglia, Pietro
AU - Pezzi, Vincenzo
N1 - Funding Information:
This work was supported by grants from the Italian Ministry of Education (MIUR) (PRIN No. 20098SJX4F) and by Associazione Italiana per la Ricerca sul Cancro (AIRC) project No. IG10344.
PY - 2013/12/1
Y1 - 2013/12/1
N2 - Resveratrol (3,4′,5 tri-hydroxystilbene), a natural plant polyphenol, has gained interest as a non-toxic agent capable of inducing tumor cell death in a variety of cancer types. However, therapeutic application of these beneficial effects remains very limited due to its short biological half-life, labile properties, rapid metabolism and elimination. Different studies were undertaken to obtain synthetic analogs of resveratrol with major bioavailability and anticancer activity. We have synthesized a series 3-chloro-azetidin-2-one derivatives, in which an azetidinone nucleus connects two aromatic rings. Aim of the present study was to investigate the effects of these new 3-chloro-azetidin-2-one resveratrol derivatives on human breast cancer cell lines proliferation. Our results indicate that some azetidin-based resveratrol derivatives may become new potent alternative tools for the treatment of human breast cancer.
AB - Resveratrol (3,4′,5 tri-hydroxystilbene), a natural plant polyphenol, has gained interest as a non-toxic agent capable of inducing tumor cell death in a variety of cancer types. However, therapeutic application of these beneficial effects remains very limited due to its short biological half-life, labile properties, rapid metabolism and elimination. Different studies were undertaken to obtain synthetic analogs of resveratrol with major bioavailability and anticancer activity. We have synthesized a series 3-chloro-azetidin-2-one derivatives, in which an azetidinone nucleus connects two aromatic rings. Aim of the present study was to investigate the effects of these new 3-chloro-azetidin-2-one resveratrol derivatives on human breast cancer cell lines proliferation. Our results indicate that some azetidin-based resveratrol derivatives may become new potent alternative tools for the treatment of human breast cancer.
KW - 3-Chloro-azetidin-2-one derivatives
KW - Breast cancer
KW - MCF-7
KW - Resveratrol analogs anticancer drugs
KW - SKBR3
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U2 - 10.1016/j.bmcl.2013.09.054
DO - 10.1016/j.bmcl.2013.09.054
M3 - Article
C2 - 24119558
AN - SCOPUS:84886946656
SN - 0960-894X
VL - 23
SP - 6401
EP - 6405
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 23
ER -