Biological effectiveness of antiproton annihilation

Michael H. Holzscheiter; Nzhde Agazaryan; Niels Bassler; Gerd Beyer; John J. DeMarco; Michael Doser; Toshiyasu Ichioka; Keisuke S. Iwamoto; Helge V. Knudsen; Rolf Landua; Carl Maggiore; William H. McBride; Søren Pape Møller; Jorgen Petersen; James B. Smathers; Lloyd D. Skarsgard; Timothy D. Solberg; Ulrik I. Uggerhøj; H. Rodney Withers; Sanja Vranjes; Michelle Wong; Bradly G. Wouters

doi:10.1016/j.nimb.2004.03.057

Biological effectiveness of antiproton annihilation

Michael H. Holzscheiter, Nzhde Agazaryan, Niels Bassler, Gerd Beyer, John J. DeMarco, Michael Doser, Toshiyasu Ichioka, Keisuke S. Iwamoto, Helge V. Knudsen, Rolf Landua, Carl Maggiore, William H. McBride, Søren Pape Møller, Jorgen Petersen, James B. Smathers, Lloyd D. Skarsgard, Timothy D. Solberg, Ulrik I. Uggerhøj, H. Rodney Withers, Sanja VranjesMichelle Wong, Bradly G. Wouters

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We describe an experiment designed to determine whether or not the densely ionizing particles emanating from the annihilation of antiprotons produce an increase in "biological dose" in the vicinity of the narrow Bragg peak for antiprotons compared to protons. This experiment is the first direct measurement of the biological effects of antiproton annihilation. The experiment has been approved by the CERN Research Board for running at the CERN Antiproton Decelerator (AD) as AD-4/ACE (Antiproton Cell Experiment) and has begun data taking in June of 2003. The background, description and the current status of the experiment are given.

Original language	English (US)
Pages (from-to)	210-214
Number of pages	5
Journal	Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Volume	221
Issue number	1-4
DOIs	https://doi.org/10.1016/j.nimb.2004.03.057
State	Published - Jul 2004

Keywords

Antiproton annihilation
Biological response
Bragg peak

ASJC Scopus subject areas

Nuclear and High Energy Physics
Instrumentation

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10.1016/j.nimb.2004.03.057

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Holzscheiter, M. H., Agazaryan, N., Bassler, N., Beyer, G., DeMarco, J. J., Doser, M., Ichioka, T., Iwamoto, K. S., Knudsen, H. V., Landua, R., Maggiore, C., McBride, W. H., Møller, S. P., Petersen, J., Smathers, J. B., Skarsgard, L. D., Solberg, T. D., Uggerhøj, U. I., Withers, H. R., ... Wouters, B. G. (2004). Biological effectiveness of antiproton annihilation. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 221(1-4), 210-214. https://doi.org/10.1016/j.nimb.2004.03.057

Holzscheiter, MH, Agazaryan, N, Bassler, N, Beyer, G, DeMarco, JJ, Doser, M, Ichioka, T, Iwamoto, KS, Knudsen, HV, Landua, R, Maggiore, C, McBride, WH, Møller, SP, Petersen, J, Smathers, JB, Skarsgard, LD, Solberg, TD, Uggerhøj, UI, Withers, HR, Vranjes, S, Wong, M & Wouters, BG 2004, 'Biological effectiveness of antiproton annihilation', Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, vol. 221, no. 1-4, pp. 210-214. https://doi.org/10.1016/j.nimb.2004.03.057

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author = "Holzscheiter, {Michael H.} and Nzhde Agazaryan and Niels Bassler and Gerd Beyer and DeMarco, {John J.} and Michael Doser and Toshiyasu Ichioka and Iwamoto, {Keisuke S.} and Knudsen, {Helge V.} and Rolf Landua and Carl Maggiore and McBride, {William H.} and M{\o}ller, {S{\o}ren Pape} and Jorgen Petersen and Smathers, {James B.} and Skarsgard, {Lloyd D.} and Solberg, {Timothy D.} and Uggerh{\o}j, {Ulrik I.} and Withers, {H. Rodney} and Sanja Vranjes and Michelle Wong and Wouters, {Bradly G.}",

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doi = "10.1016/j.nimb.2004.03.057",

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T1 - Biological effectiveness of antiproton annihilation

AU - Holzscheiter, Michael H.

AU - Agazaryan, Nzhde

AU - Bassler, Niels

AU - Beyer, Gerd

AU - DeMarco, John J.

AU - Doser, Michael

AU - Ichioka, Toshiyasu

AU - Iwamoto, Keisuke S.

AU - Knudsen, Helge V.

AU - Landua, Rolf

AU - Maggiore, Carl

AU - McBride, William H.

AU - Møller, Søren Pape

AU - Petersen, Jorgen

AU - Smathers, James B.

AU - Skarsgard, Lloyd D.

AU - Solberg, Timothy D.

AU - Uggerhøj, Ulrik I.

AU - Withers, H. Rodney

AU - Vranjes, Sanja

AU - Wong, Michelle

AU - Wouters, Bradly G.

PY - 2004/7

Y1 - 2004/7

N2 - We describe an experiment designed to determine whether or not the densely ionizing particles emanating from the annihilation of antiprotons produce an increase in "biological dose" in the vicinity of the narrow Bragg peak for antiprotons compared to protons. This experiment is the first direct measurement of the biological effects of antiproton annihilation. The experiment has been approved by the CERN Research Board for running at the CERN Antiproton Decelerator (AD) as AD-4/ACE (Antiproton Cell Experiment) and has begun data taking in June of 2003. The background, description and the current status of the experiment are given.

AB - We describe an experiment designed to determine whether or not the densely ionizing particles emanating from the annihilation of antiprotons produce an increase in "biological dose" in the vicinity of the narrow Bragg peak for antiprotons compared to protons. This experiment is the first direct measurement of the biological effects of antiproton annihilation. The experiment has been approved by the CERN Research Board for running at the CERN Antiproton Decelerator (AD) as AD-4/ACE (Antiproton Cell Experiment) and has begun data taking in June of 2003. The background, description and the current status of the experiment are given.

KW - Antiproton annihilation

KW - Biological response

KW - Bragg peak

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JF - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms

IS - 1-4

ER -

Biological effectiveness of antiproton annihilation

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