TY - JOUR
T1 - Biological Properties of a Type C Virus Isolated from a Human X Mouse Hybrid Cell Line
AU - Gazdar, A. F.
AU - Russell, E. K.
AU - Minna, J.
PY - 1975/7
Y1 - 1975/7
N2 - The biological properties of the HMV · 1 virus, spontaneously released from a human X C57BL/6 mouse hybrid cell line, were similar to those of RadLV, the prototype B-tropic virus of C57BL/6 mice. Both viruses replicated on B-type mouse cells and in the wild mouse cell line SC-1. The plaque-forming abilities of the two viruses were relatively low, but gradually increased after passage in new host cells. Both viruses were neutralized by AKR antisera but not by FMR antisera. HMV·1 virus could rescue the defective sarcoma genome from S+H— mouse cells. The pseudotype sarcoma virus so produced was deficient in “helper virus” activity. Newborn mice inoculated with HMV · 1 virus remained tumor-free over a 1-yr observation period.
AB - The biological properties of the HMV · 1 virus, spontaneously released from a human X C57BL/6 mouse hybrid cell line, were similar to those of RadLV, the prototype B-tropic virus of C57BL/6 mice. Both viruses replicated on B-type mouse cells and in the wild mouse cell line SC-1. The plaque-forming abilities of the two viruses were relatively low, but gradually increased after passage in new host cells. Both viruses were neutralized by AKR antisera but not by FMR antisera. HMV·1 virus could rescue the defective sarcoma genome from S+H— mouse cells. The pseudotype sarcoma virus so produced was deficient in “helper virus” activity. Newborn mice inoculated with HMV · 1 virus remained tumor-free over a 1-yr observation period.
UR - http://www.scopus.com/inward/record.url?scp=0016696084&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016696084&partnerID=8YFLogxK
U2 - 10.3181/00379727-149-38880
DO - 10.3181/00379727-149-38880
M3 - Article
C2 - 49896
AN - SCOPUS:0016696084
VL - 149
SP - 688
EP - 692
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
SN - 1535-3702
IS - 3
ER -