Biological Properties of a Type C Virus Isolated from a Human X Mouse Hybrid Cell Line

A. F. Gazdar, E. K. Russell, J. Minna

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The biological properties of the HMV · 1 virus, spontaneously released from a human X C57BL/6 mouse hybrid cell line, were similar to those of RadLV, the prototype B-tropic virus of C57BL/6 mice. Both viruses replicated on B-type mouse cells and in the wild mouse cell line SC-1. The plaque-forming abilities of the two viruses were relatively low, but gradually increased after passage in new host cells. Both viruses were neutralized by AKR antisera but not by FMR antisera. HMV·1 virus could rescue the defective sarcoma genome from S+H— mouse cells. The pseudotype sarcoma virus so produced was deficient in “helper virus” activity. Newborn mice inoculated with HMV · 1 virus remained tumor-free over a 1-yr observation period.

Original languageEnglish (US)
Pages (from-to)688-692
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume149
Issue number3
DOIs
StatePublished - Jul 1975

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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