Biomarker enables molecular specific optical detection of transplant rejection

Qiang Tu, Yoon Gi Chung, Dianjun Cao, Shuko Harada, Christine S. Cheng, Howard J. Eisen, Chang Chang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Using serotonin as the biomarker, spatially re-solved Raman spectroscopy successfully detects heart transplant rejection without exogenous labeling and chemical fixation. The strong and characteristic Raman spectral signature of serotonin enables this direct optical detection without re-sorting to complicated data processing procedures. As the role of serotonin in various immune responses becomes increasingly recognized, this work presents a new paradigm in utilizing Raman spectroscopy as a clinically viable molecular specific diagnostic tool.

Original languageEnglish (US)
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationDiagnostic and Therapeutic Instrumentation, Clinical Engineering
PublisherSpringer Verlag
Pages740-743
Number of pages4
Edition7
ISBN (Print)9783642038846
DOIs
StatePublished - 2009
EventWorld Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering - Munich, Germany
Duration: Sep 7 2009Sep 12 2009

Publication series

NameIFMBE Proceedings
Number7
Volume25
ISSN (Print)1680-0737

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering
CountryGermany
CityMunich
Period9/7/099/12/09

Keywords

  • Cardiac allograft
  • Heart transplantation
  • Raman spectroscopy
  • Rejection surveillance
  • Serotonin

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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