Biomarker enables molecular specific optical detection of transplant rejection

Qiang Tu, Yoon Gi Chung, Dianjun Cao, Shuko Harada, Christine S. Cheng, Howard J. Eisen, Chang Chang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Using serotonin as the biomarker, spatially re-solved Raman spectroscopy successfully detects heart transplant rejection without exogenous labeling and chemical fixation. The strong and characteristic Raman spectral signature of serotonin enables this direct optical detection without re-sorting to complicated data processing procedures. As the role of serotonin in various immune responses becomes increasingly recognized, this work presents a new paradigm in utilizing Raman spectroscopy as a clinically viable molecular specific diagnostic tool.

Original languageEnglish (US)
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationDiagnostic and Therapeutic Instrumentation, Clinical Engineering
Pages740-743
Number of pages4
Volume25
Edition7
DOIs
StatePublished - 2009
EventWorld Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering - Munich, Germany
Duration: Sep 7 2009Sep 12 2009

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering
CountryGermany
CityMunich
Period9/7/099/12/09

Fingerprint

Transplants
Biomarkers
Raman spectroscopy
Serotonin
Sorting
Labeling

Keywords

  • Cardiac allograft
  • Heart transplantation
  • Raman spectroscopy
  • Rejection surveillance
  • Serotonin

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

Cite this

Tu, Q., Chung, Y. G., Cao, D., Harada, S., Cheng, C. S., Eisen, H. J., & Chang, C. (2009). Biomarker enables molecular specific optical detection of transplant rejection. In World Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering (7 ed., Vol. 25, pp. 740-743) https://doi.org/10.1007/978-3-642-03885-3-205

Biomarker enables molecular specific optical detection of transplant rejection. / Tu, Qiang; Chung, Yoon Gi; Cao, Dianjun; Harada, Shuko; Cheng, Christine S.; Eisen, Howard J.; Chang, Chang.

World Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering. Vol. 25 7. ed. 2009. p. 740-743.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tu, Q, Chung, YG, Cao, D, Harada, S, Cheng, CS, Eisen, HJ & Chang, C 2009, Biomarker enables molecular specific optical detection of transplant rejection. in World Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering. 7 edn, vol. 25, pp. 740-743, World Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering, Munich, Germany, 9/7/09. https://doi.org/10.1007/978-3-642-03885-3-205
Tu Q, Chung YG, Cao D, Harada S, Cheng CS, Eisen HJ et al. Biomarker enables molecular specific optical detection of transplant rejection. In World Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering. 7 ed. Vol. 25. 2009. p. 740-743 https://doi.org/10.1007/978-3-642-03885-3-205
Tu, Qiang ; Chung, Yoon Gi ; Cao, Dianjun ; Harada, Shuko ; Cheng, Christine S. ; Eisen, Howard J. ; Chang, Chang. / Biomarker enables molecular specific optical detection of transplant rejection. World Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering. Vol. 25 7. ed. 2009. pp. 740-743
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