Biomarker enables molecular specific optical detection of transplant rejection

Qiang Tu, Yoon Gi Chung, Dianjun Cao, Shuko Harada, Christine S. Cheng, Howard J. Eisen, Chang Chang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Using serotonin as the biomarker, spatially re-solved Raman spectroscopy successfully detects heart transplant rejection without exogenous labeling and chemical fixation. The strong and characteristic Raman spectral signature of serotonin enables this direct optical detection without re-sorting to complicated data processing procedures. As the role of serotonin in various immune responses becomes increasingly recognized, this work presents a new paradigm in utilizing Raman spectroscopy as a clinically viable molecular specific diagnostic tool.

Original languageEnglish (US)
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationDiagnostic and Therapeutic Instrumentation, Clinical Engineering
Pages740-743
Number of pages4
Edition7
DOIs
StatePublished - Dec 1 2009
EventWorld Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering - Munich, Germany
Duration: Sep 7 2009Sep 12 2009

Publication series

NameIFMBE Proceedings
Number7
Volume25
ISSN (Print)1680-0737

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering
CountryGermany
CityMunich
Period9/7/099/12/09

Keywords

  • Cardiac allograft
  • Heart transplantation
  • Raman spectroscopy
  • Rejection surveillance
  • Serotonin

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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  • Cite this

    Tu, Q., Chung, Y. G., Cao, D., Harada, S., Cheng, C. S., Eisen, H. J., & Chang, C. (2009). Biomarker enables molecular specific optical detection of transplant rejection. In World Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering (7 ed., pp. 740-743). (IFMBE Proceedings; Vol. 25, No. 7). https://doi.org/10.1007/978-3-642-03885-3-205