@inproceedings{3e71c1a0fe004271a088e120de03d8e1,
title = "Biomarker enables molecular specific optical detection of transplant rejection",
abstract = "Using serotonin as the biomarker, spatially re-solved Raman spectroscopy successfully detects heart transplant rejection without exogenous labeling and chemical fixation. The strong and characteristic Raman spectral signature of serotonin enables this direct optical detection without re-sorting to complicated data processing procedures. As the role of serotonin in various immune responses becomes increasingly recognized, this work presents a new paradigm in utilizing Raman spectroscopy as a clinically viable molecular specific diagnostic tool.",
keywords = "Cardiac allograft, Heart transplantation, Raman spectroscopy, Rejection surveillance, Serotonin",
author = "Qiang Tu and Chung, {Yoon Gi} and Dianjun Cao and Shuko Harada and Cheng, {Christine S.} and Eisen, {Howard J.} and Chang Chang",
year = "2009",
doi = "10.1007/978-3-642-03885-3_205",
language = "English (US)",
isbn = "9783642038846",
series = "IFMBE Proceedings",
publisher = "Springer Verlag",
number = "7",
pages = "740--743",
booktitle = "World Congress on Medical Physics and Biomedical Engineering",
edition = "7",
note = "World Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering ; Conference date: 07-09-2009 Through 12-09-2009",
}