Biomarkers for sporadic Creutzfeldt-Jakob disease

Sanam Soomro, Chandra Mohan

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare but fatal type of spongiform encephalopathy with unknown cause. Unfortunately, definitive diagnosis of this disease can only be done by examination of postmortem brain tissue. Presumptive diagnosis is done through a combination of clinical manifestations, radiology results, and cerebrospinal fluid (CSF) testing for CSF 14-3-3. Even with these guidelines, premortem diagnosis of sCJD can be unreliable with high rates of misdiagnosis. This calls for more reliable biomarkers of the disease, allowing for better diagnosis as well as understanding the pathogenesis of sCJD. This review compiles potential genetic, protein, biomolecular, and imaging biomarker studies for sCJD since 2010, highlighting the promise of proteins, cytokines, and composite biomarkers for improving the diagnosis as well as understanding the pathogenesis of this mysterious ailment.

Original languageEnglish (US)
Pages (from-to)465-472
Number of pages8
JournalAnnals of Clinical and Translational Neurology
Volume3
Issue number6
DOIs
StatePublished - Jun 1 2016

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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