TY - JOUR
T1 - Biomarkers of An Autoimmune Skin Disease-Psoriasis
AU - Jiang, Shan
AU - Hinchliffe, Taylor E.
AU - Wu, Tianfu
N1 - Funding Information:
The authors are grateful for the technical assistance and helpful discussions from Zuan-Tao Lin and Xuezhu Zhang. This work was partly supported by the startup funds provided to TW by the University of Houston , USA.
Publisher Copyright:
© 2015 The Authors.
PY - 2015/8
Y1 - 2015/8
N2 - Psoriasis is one of the most prevalent autoimmune skin diseases. However, its etiology and pathogenesis are still unclear. Over the last decade, omics-based technologies have been extensively utilized for biomarker discovery. As a result, some promising markers for psoriasis have been identified at the genome, transcriptome, proteome, and metabolome level. These discoveries have provided new insights into the underlying molecular mechanisms and signaling pathways in psoriasis pathogenesis. More importantly, some of these markers may prove useful in the diagnosis of psoriasis and in the prediction of disease progression once they have been validated. In this review, we summarize the most recent findings in psoriasis biomarker discovery. In addition, we will discuss several emerging technologies and their potential for novel biomarker discovery and diagnostics for psoriasis.
AB - Psoriasis is one of the most prevalent autoimmune skin diseases. However, its etiology and pathogenesis are still unclear. Over the last decade, omics-based technologies have been extensively utilized for biomarker discovery. As a result, some promising markers for psoriasis have been identified at the genome, transcriptome, proteome, and metabolome level. These discoveries have provided new insights into the underlying molecular mechanisms and signaling pathways in psoriasis pathogenesis. More importantly, some of these markers may prove useful in the diagnosis of psoriasis and in the prediction of disease progression once they have been validated. In this review, we summarize the most recent findings in psoriasis biomarker discovery. In addition, we will discuss several emerging technologies and their potential for novel biomarker discovery and diagnostics for psoriasis.
KW - Biomarker
KW - Genomics
KW - Metabolomics
KW - Proteomics
KW - Psoriasis
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U2 - 10.1016/j.gpb.2015.04.002
DO - 10.1016/j.gpb.2015.04.002
M3 - Review article
C2 - 26362816
AN - SCOPUS:84944383787
SN - 1672-0229
VL - 13
SP - 224
EP - 233
JO - Genomics, Proteomics and Bioinformatics
JF - Genomics, Proteomics and Bioinformatics
IS - 4
M1 - 162
ER -