Biomarkers of memory variability in traumatic brain injury

Richard Adamovich-Zeitlin, Paul A. Wanda, Ethan Solomon, Tung Phan, Bradley Lega, Barbara C. Jobst, Robert E. Gross, Kan Ding, Ramon Diaz-Arrastia, Michael J. Kahana

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Traumatic brain injury is a leading cause of cognitive disability and is often associated with significant impairment in episodic memory. In traumatic brain Injury survivors, as in healthy controls, there is marked variability between individuals in memory ability. Using recordings from indwelling electrodes, we characterized and compared the oscillatory biomarkers of mnemonic variability in two cohorts of epilepsy patients: A group with a history of moderate-To-severe traumatic brain injury (n = 37) and a group of controls without traumatic brain injury (n = 111) closely matched for demographics and electrode coverage. Analysis of these recordings demonstrated that increased high-frequency power and decreased theta power across a broad set of brain regions mark periods of successful memory formation in both groups. As features in a logistic-regression classifier, spectral power biomarkers effectively predicted recall probability, with little difference between traumatic brain injury patients and controls. The two groups also displayed similar patterns of theta-frequency connectivity during successful encoding periods. These biomarkers of successful memory, highly conserved between traumatic brain injury patients and controls, could serve as the basis for novel therapies that target disordered memory across diverse forms of neurological disease.

Original languageEnglish (US)
Article numberfcaa202
JournalBrain Communications
Volume3
Issue number1
DOIs
StatePublished - 2021

Keywords

  • Episodic memory
  • Intracranial eeg
  • Recall
  • Theta
  • Traumatic brain injury

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Cellular and Molecular Neuroscience
  • Neurology

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