Biomarkers of rheumatoid arthritis: Recent progress

Tianfu Wu, Deena Sajitharan, Chandra Mohan

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Importance of the field: Biomarkers are emerging as vital tools for early diagnosis, prognostication and disease management in chronic diseases, including rheumatoid arthritis (RA). Areas covered in this review: This review discusses diagnostic, prognostic and theranostic biomarker candidates for RA that are being studied at present. What the reader will gain: The reader will gain a better understanding of the different classes of markers being proposed as potential biomarkers for RA, and how they compare with each other. Take home message: At present, several molecules are showing varying degrees of promise as potential biomarkers in RA. These include serum rheumatoid factors and anti-cyclic citrullinated protein antibodies, a couple of acute phase proteins and pro-inflammatory cytokines expressed in the serum and/or diseased joints, notably IL-1, IL-6, TNF-α, MCP-1 and MIP-α, as well as molecules released by damaged synovial tissue, cartilage and bone. Continuing proteomic and metabolomic efforts are rapidly expanding this repertoire of potential biomarker candidates. Large-scale longitudinal trials are clearly needed where several biomarker candidates can be assessed in parallel, relative to current yardsticks. The ultimate goal is to distill out a subset of informative biomarkers, presumably representing distinct pathogenic pathways, which will enable the rheumatologist to prognosticate, predict and actively manage the disease course in RA.

Original languageEnglish (US)
Pages (from-to)293-305
Number of pages13
JournalExpert Opinion on Medical Diagnostics
Volume4
Issue number4
DOIs
StatePublished - Jul 1 2010

    Fingerprint

Keywords

  • Biomarkers
  • Diagnostics
  • Proteomics
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Medicine
  • Biochemistry, medical

Cite this