Biomarkers provide clues to early events in the pathogenesis of breast implant-associated anaplastic large cell lymphoma

Marshall E. Kadin, Anand Deva, Haiying Xu, John Morgan, Pranay Khare, Roderick A.F. MacLeod, Bruce W. Van Natta, William P. Adams, Garry S. Brody, Alan L. Epstein

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

Almost 200 women worldwide have been diagnosed with breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The unique location and specific lymphoma type strongly suggest an etio-pathologic link between breast implants and BIA-ALCL. It is postulated that chronic inflammation via bacterial infection may be an etiological factor. BIA-ALCL resembles primary cutaneous ALCL ( pcALCL) in morphology, activated T-cell phenotype, and indolent clinical course. Gene expression array analysis, flow cytometry, and immunohistochemistry were used to study pcALCL and BIA-ALCL cell lines. Clinical samples were also studied to characterize transcription factor and cytokine profiles of tumor cells and surrounding lymphocytes. BIA-ALCL and pcALCL were found to have common expression of transcription factors SOCS3, JunB, SATB1, and a cytokine profile suggestive of a Th1 phenotype. Similar patterns were observed in a CD30+ cutaneous lymphoproliferative disorder (LPD). The patterns of cytokine and transcription factor expression suggest that BIAALCL is likely to arise from chronic bacterial antigen stimulation of T-cells. Further analysis of cytokine and transcription factor profiles may allow early detection and treatment of BIA-ALCL leading to better prognosis and survival.

Original languageEnglish (US)
Pages (from-to)773-781
Number of pages9
JournalAesthetic surgery journal
Volume36
Issue number7
DOIs
StatePublished - Jul 1 2016

ASJC Scopus subject areas

  • Surgery

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    Kadin, M. E., Deva, A., Xu, H., Morgan, J., Khare, P., MacLeod, R. A. F., Van Natta, B. W., Adams, W. P., Brody, G. S., & Epstein, A. L. (2016). Biomarkers provide clues to early events in the pathogenesis of breast implant-associated anaplastic large cell lymphoma. Aesthetic surgery journal, 36(7), 773-781. https://doi.org/10.1093/asj/sjw023