Biomarkers provide clues to early events in the pathogenesis of breast implant-associated anaplastic large cell lymphoma

Marshall E. Kadin, Anand Deva, Haiying Xu, John Morgan, Pranay Khare, Roderick A.F. MacLeod, Bruce W. Van Natta, William P. Adams, Garry S. Brody, Alan L. Epstein

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Almost 200 women worldwide have been diagnosed with breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The unique location and specific lymphoma type strongly suggest an etio-pathologic link between breast implants and BIA-ALCL. It is postulated that chronic inflammation via bacterial infection may be an etiological factor. BIA-ALCL resembles primary cutaneous ALCL ( pcALCL) in morphology, activated T-cell phenotype, and indolent clinical course. Gene expression array analysis, flow cytometry, and immunohistochemistry were used to study pcALCL and BIA-ALCL cell lines. Clinical samples were also studied to characterize transcription factor and cytokine profiles of tumor cells and surrounding lymphocytes. BIA-ALCL and pcALCL were found to have common expression of transcription factors SOCS3, JunB, SATB1, and a cytokine profile suggestive of a Th1 phenotype. Similar patterns were observed in a CD30+ cutaneous lymphoproliferative disorder (LPD). The patterns of cytokine and transcription factor expression suggest that BIAALCL is likely to arise from chronic bacterial antigen stimulation of T-cells. Further analysis of cytokine and transcription factor profiles may allow early detection and treatment of BIA-ALCL leading to better prognosis and survival.

Original languageEnglish (US)
Pages (from-to)773-781
Number of pages9
JournalAesthetic Surgery Journal
Volume36
Issue number7
DOIs
StatePublished - Jul 1 2016

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Anaplastic Large-Cell Lymphoma
Breast Implants
Biomarkers
Primary Cutaneous Anaplastic Large Cell Lymphoma
Transcription Factors
Cytokines
Bacterial Antigens
T-Lymphocytes
Phenotype
Skin
Lymphoproliferative Disorders
Bacterial Infections
Lymphoma
Flow Cytometry
Immunohistochemistry
Lymphocytes
Inflammation
Gene Expression
Cell Line
Survival

ASJC Scopus subject areas

  • Surgery

Cite this

Kadin, M. E., Deva, A., Xu, H., Morgan, J., Khare, P., MacLeod, R. A. F., ... Epstein, A. L. (2016). Biomarkers provide clues to early events in the pathogenesis of breast implant-associated anaplastic large cell lymphoma. Aesthetic Surgery Journal, 36(7), 773-781. https://doi.org/10.1093/asj/sjw023

Biomarkers provide clues to early events in the pathogenesis of breast implant-associated anaplastic large cell lymphoma. / Kadin, Marshall E.; Deva, Anand; Xu, Haiying; Morgan, John; Khare, Pranay; MacLeod, Roderick A.F.; Van Natta, Bruce W.; Adams, William P.; Brody, Garry S.; Epstein, Alan L.

In: Aesthetic Surgery Journal, Vol. 36, No. 7, 01.07.2016, p. 773-781.

Research output: Contribution to journalArticle

Kadin, ME, Deva, A, Xu, H, Morgan, J, Khare, P, MacLeod, RAF, Van Natta, BW, Adams, WP, Brody, GS & Epstein, AL 2016, 'Biomarkers provide clues to early events in the pathogenesis of breast implant-associated anaplastic large cell lymphoma', Aesthetic Surgery Journal, vol. 36, no. 7, pp. 773-781. https://doi.org/10.1093/asj/sjw023
Kadin, Marshall E. ; Deva, Anand ; Xu, Haiying ; Morgan, John ; Khare, Pranay ; MacLeod, Roderick A.F. ; Van Natta, Bruce W. ; Adams, William P. ; Brody, Garry S. ; Epstein, Alan L. / Biomarkers provide clues to early events in the pathogenesis of breast implant-associated anaplastic large cell lymphoma. In: Aesthetic Surgery Journal. 2016 ; Vol. 36, No. 7. pp. 773-781.
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