TY - JOUR
T1 - Biomaterial implants mediate autologous stem cell recruitment in mice
AU - Nair, A.
AU - Shen, J.
AU - Lotfi, P.
AU - Ko, C. Y.
AU - Zhang, Chengcheng
AU - Tang, L.
N1 - Funding Information:
This work was supported by NIH Grant EB007271 AHA South Central Affiliate Grant-in-Aid. The authors would also like to thank Paul Thevenot for help with in vitro differentiation study.
PY - 2011/11
Y1 - 2011/11
N2 - Autologous stem cells, recognized as the best cells for stem cell therapy, are associated with difficult extraction procedures which often lead to more traumas for the patients and time-consuming laboratory work, which delays their subsequent application. To combat such challenges, it was recently uncovered that, shortly after biomaterial implantation, following the recruitment of inflammatory cells, substantial numbers of mesenchymal stem cells (MSC) and hematopoietic stem cells (HSC) were recruited to the implantation sites. These multipotent MSC could be differentiated into various lineages in vitro. Inflammatory signals may be responsible for the gathering of stem cells, since there is a good relationship between biomaterial-mediated inflammatory responses and stem cell accumulation in vivo. In addition, the treatment with the anti-inflammatory drug dexamethasone substantially reduced the recruitment of both MSC and HSC. The results from this work support that such strategies could be further developed towards localized recruitment and differentiation of progenitor cells. This may permit the future development of autologous stem cell therapies without the need for tedious cell isolation, culture and transplantation.
AB - Autologous stem cells, recognized as the best cells for stem cell therapy, are associated with difficult extraction procedures which often lead to more traumas for the patients and time-consuming laboratory work, which delays their subsequent application. To combat such challenges, it was recently uncovered that, shortly after biomaterial implantation, following the recruitment of inflammatory cells, substantial numbers of mesenchymal stem cells (MSC) and hematopoietic stem cells (HSC) were recruited to the implantation sites. These multipotent MSC could be differentiated into various lineages in vitro. Inflammatory signals may be responsible for the gathering of stem cells, since there is a good relationship between biomaterial-mediated inflammatory responses and stem cell accumulation in vivo. In addition, the treatment with the anti-inflammatory drug dexamethasone substantially reduced the recruitment of both MSC and HSC. The results from this work support that such strategies could be further developed towards localized recruitment and differentiation of progenitor cells. This may permit the future development of autologous stem cell therapies without the need for tedious cell isolation, culture and transplantation.
KW - Autologous stem cells
KW - Flow cytometry
KW - Foreign body response
KW - Hematopoietic stem cells
KW - Mesenchymal stem cells
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U2 - 10.1016/j.actbio.2011.06.050
DO - 10.1016/j.actbio.2011.06.050
M3 - Article
C2 - 21784181
AN - SCOPUS:80053574516
SN - 1742-7061
VL - 7
SP - 3887
EP - 3895
JO - Acta Biomaterialia
JF - Acta Biomaterialia
IS - 11
ER -