Biomaterial implants mediate autologous stem cell recruitment in mice

A. Nair, J. Shen, P. Lotfi, C. Y. Ko, Chengcheng Zhang, L. Tang

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Autologous stem cells, recognized as the best cells for stem cell therapy, are associated with difficult extraction procedures which often lead to more traumas for the patients and time-consuming laboratory work, which delays their subsequent application. To combat such challenges, it was recently uncovered that, shortly after biomaterial implantation, following the recruitment of inflammatory cells, substantial numbers of mesenchymal stem cells (MSC) and hematopoietic stem cells (HSC) were recruited to the implantation sites. These multipotent MSC could be differentiated into various lineages in vitro. Inflammatory signals may be responsible for the gathering of stem cells, since there is a good relationship between biomaterial-mediated inflammatory responses and stem cell accumulation in vivo. In addition, the treatment with the anti-inflammatory drug dexamethasone substantially reduced the recruitment of both MSC and HSC. The results from this work support that such strategies could be further developed towards localized recruitment and differentiation of progenitor cells. This may permit the future development of autologous stem cell therapies without the need for tedious cell isolation, culture and transplantation.

Original languageEnglish (US)
Pages (from-to)3887-3895
Number of pages9
JournalActa Biomaterialia
Volume7
Issue number11
DOIs
StatePublished - Nov 1 2011

    Fingerprint

Keywords

  • Autologous stem cells
  • Flow cytometry
  • Foreign body response
  • Hematopoietic stem cells
  • Mesenchymal stem cells

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Cite this