Biomechanical properties of bone and cartilage in growing femoral head following ischemic osteonecrosis

Thomas J. Koob, Douglas Pringle, Emily Gedbaw, James Meredith, Ricardo Berrios, Harry K W Kim

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Legg-Calve-Perthes disease (LCPD) is one of the most common causes of a permanent deformity of the femoral head among pediatric hip disorders. Mechanical loading of the osteonecrotic femoral head undergoing repair is thought play a significant role in the development of the femoral head deformity. This study measured the mechanical properties in uniaxial unconfined compression tests of epiphyseal bone and cartilage from immature femoral heads following surgical induction of osteonecrosis using an established piglet model. Both the modulus and yield strength of bone cores from the infarcted heads were significantly lower by 50%-60% than those of the contralateral normal control heads by 2 weeks after surgery and they remained this low for 8 weeks. No consistent difference in the bone mineral or collagen content per dry weight in the bone cores was observed. Cartilage modulus and yield strength were significantly lower at 2 weeks and remained low for 8 weeks. Cartilage collagen and glycosaminoglycan content per dry weight did not differ significantly between control and infarcted heads at any time point. However, the relative proportion of chondroitin 6-sulfate increased significantly over the 8-week postoperative period, which correlated with an increase in cartilage thickness. These results indicate that the deterioration of the mechanical properties of the epiphyseal bone and cartilage likely plays a significant role in the pathogenesis of the femoral head deformity in LCPD.

Original languageEnglish (US)
Pages (from-to)750-757
Number of pages8
JournalJournal of Orthopaedic Research
Volume25
Issue number6
DOIs
StatePublished - Jun 2007

Fingerprint

Osteonecrosis
Thigh
Cartilage
Bone and Bones
Legg-Calve-Perthes Disease
Growth Plate
Head
Weights and Measures
Chondroitin Sulfates
Glycosaminoglycans
Postoperative Period
Minerals
Hip
Collagen
Pediatrics
Coxa Magna

Keywords

  • Avascular necrosis
  • Biomechanical
  • Femoral head
  • Ischemic necrosis
  • Osteonecrosis

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Biomechanical properties of bone and cartilage in growing femoral head following ischemic osteonecrosis. / Koob, Thomas J.; Pringle, Douglas; Gedbaw, Emily; Meredith, James; Berrios, Ricardo; Kim, Harry K W.

In: Journal of Orthopaedic Research, Vol. 25, No. 6, 06.2007, p. 750-757.

Research output: Contribution to journalArticle

Koob, Thomas J. ; Pringle, Douglas ; Gedbaw, Emily ; Meredith, James ; Berrios, Ricardo ; Kim, Harry K W. / Biomechanical properties of bone and cartilage in growing femoral head following ischemic osteonecrosis. In: Journal of Orthopaedic Research. 2007 ; Vol. 25, No. 6. pp. 750-757.
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