Biomimetic nanocarrier for direct cytosolic drug delivery

Zhihong Zhang, Weiguo Cao, Honglin Jin, Jonathan F. Lovell, Mi Yang, Lili Ding, Juan Chen, Ian Corbin, Qingming Luo, Gang Zheng

Research output: Contribution to journalArticle

118 Scopus citations

Abstract

Getting straight to the point: A peptide-phospholipid-based biomimetic nanocarrier was developed that can transport cargo molecules directly into cytosolic compartments through a non-endocytotic uptake mechanism mediated by scavenger receptor class B type I (SR-BI ; see schematic illustration). The fluorescent image shows the cytosolic localization of a dye (red) delivered by the nanocarrier to SR-BI-positive cells (nuclei: blue, membranes: cyan).

Original languageEnglish (US)
Pages (from-to)9171-9175
Number of pages5
JournalAngewandte Chemie - International Edition
Volume48
Issue number48
DOIs
StatePublished - Nov 16 2009

Keywords

  • Biomimetic structures
  • Cytosol
  • Drug delivery
  • Nanocarriers
  • Peptides

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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  • Cite this

    Zhang, Z., Cao, W., Jin, H., Lovell, J. F., Yang, M., Ding, L., Chen, J., Corbin, I., Luo, Q., & Zheng, G. (2009). Biomimetic nanocarrier for direct cytosolic drug delivery. Angewandte Chemie - International Edition, 48(48), 9171-9175. https://doi.org/10.1002/anie.200903112