Biomolecular Condensates and Gene Activation in Development and Disease

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Coupling gene activity to the formation of condensates is proposed to enable the robust and precise changes in gene expression during development. In this review, Benjamin Sabari describes the emerging role of condensates in gene activation, the features of macromolecules enabling this process, condensate regulation in development, and condensate dysregulation in diseases.

Original languageEnglish (US)
Pages (from-to)84-96
Number of pages13
JournalDevelopmental cell
Volume55
Issue number1
DOIs
StatePublished - Oct 12 2020

Keywords

  • biomolecular condensates
  • gene regulation
  • gene regulation in development and disease
  • phase separation

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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