Biomolecular condensates: organizers of cellular biochemistry

Salman F. Banani, Hyun O. Lee, Anthony A. Hyman, Michael K. Rosen

Research output: Contribution to journalArticle

557 Citations (Scopus)

Abstract

Biomolecular condensates are micron-scale compartments in eukaryotic cells that lack surrounding membranes but function to concentrate proteins and nucleic acids. These condensates are involved in diverse processes, including RNA metabolism, ribosome biogenesis, the DNA damage response and signal transduction. Recent studies have shown that liquid–liquid phase separation driven by multivalent macromolecular interactions is an important organizing principle for biomolecular condensates. With this physical framework, it is now possible to explain how the assembly, composition, physical properties and biochemical and cellular functions of these important structures are regulated.

Original languageEnglish (US)
JournalNature Reviews Molecular Cell Biology
DOIs
StateAccepted/In press - Feb 22 2017

Fingerprint

Eukaryotic Cells
Ribosomes
Biochemistry
Nucleic Acids
DNA Damage
Signal Transduction
RNA
Membranes
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Biomolecular condensates : organizers of cellular biochemistry. / Banani, Salman F.; Lee, Hyun O.; Hyman, Anthony A.; Rosen, Michael K.

In: Nature Reviews Molecular Cell Biology, 22.02.2017.

Research output: Contribution to journalArticle

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