Bipartite gating in the outer membrane protein FecA

D. Van der Helm, R. Chakraborty, A. D. Ferguson, B. S. Smith, L. Esser, J. Deisenhofer

Research output: Contribution to journalArticle

10 Scopus citations


The recent structure determination of FecA, with and without ligand, shows the existence of two gates. These are the extracellular loops closing over the binding site and the plug located inside the barrel. It indicates a process which is described as bipartite gating and allows for a rational distinction between the binding event and the transport process.

Original languageEnglish (US)
Pages (from-to)708-710
Number of pages3
JournalBiochemical Society Transactions
Issue number4
Publication statusPublished - Aug 2002



  • Binding
  • Closure
  • Transport

ASJC Scopus subject areas

  • Biochemistry

Cite this

Van der Helm, D., Chakraborty, R., Ferguson, A. D., Smith, B. S., Esser, L., & Deisenhofer, J. (2002). Bipartite gating in the outer membrane protein FecA. Biochemical Society Transactions, 30(4), 708-710.