Bipartite gating in the outer membrane protein FecA

D. Van der Helm; R. Chakraborty; A. D. Ferguson; B. S. Smith; L. Esser; J. Deisenhofer

doi:10.1042/BST0300708

Bipartite gating in the outer membrane protein FecA

D. Van der Helm, R. Chakraborty, A. D. Ferguson, B. S. Smith, L. Esser, J. Deisenhofer

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The recent structure determination of FecA, with and without ligand, shows the existence of two gates. These are the extracellular loops closing over the binding site and the plug located inside the barrel. It indicates a process which is described as bipartite gating and allows for a rational distinction between the binding event and the transport process.

Original language	English (US)
Pages (from-to)	708-710
Number of pages	3
Journal	Biochemical Society Transactions
Volume	30
Issue number	4
DOIs	https://doi.org/10.1042/BST0300708
State	Published - Aug 2002

Keywords

Binding
Closure
Transport

ASJC Scopus subject areas

Biochemistry

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10.1042/BST0300708

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title = "Bipartite gating in the outer membrane protein FecA",

abstract = "The recent structure determination of FecA, with and without ligand, shows the existence of two gates. These are the extracellular loops closing over the binding site and the plug located inside the barrel. It indicates a process which is described as bipartite gating and allows for a rational distinction between the binding event and the transport process.",

keywords = "Binding, Closure, Transport",

author = "{Van der Helm}, D. and R. Chakraborty and Ferguson, {A. D.} and Smith, {B. S.} and L. Esser and J. Deisenhofer",

year = "2002",

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AU - Chakraborty, R.

AU - Ferguson, A. D.

AU - Smith, B. S.

AU - Esser, L.

AU - Deisenhofer, J.

PY - 2002/8

Y1 - 2002/8

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AB - The recent structure determination of FecA, with and without ligand, shows the existence of two gates. These are the extracellular loops closing over the binding site and the plug located inside the barrel. It indicates a process which is described as bipartite gating and allows for a rational distinction between the binding event and the transport process.

KW - Binding

KW - Closure

KW - Transport

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Bipartite gating in the outer membrane protein FecA

Abstract

Keywords

ASJC Scopus subject areas

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