Birdshot Retinochoroidopathy: Differences in Clinical Characteristics between Patients with Early and Late Age of Onset

Sukhum Silpa-archa, Jennifer H. Cao, Sutasinee Boonsopon, Joan Lee, Janine M. Preble, C. Stephen Foster

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To describe differences in the clinical characteristics of birdshot retinochoroidopathy (BSRC) patients diagnosed early and later in life. Methods: This is a retrospective cohort study. Age was primarily analyzed and 50 years of age at diagnosis was selected as a cut-off point. Results: A total of 144 patients (288 eyes) were included; 68 with early-onset and 76 with late-onset BSRC. The younger group had a statistically significant higher rate of more severe iritis (p = 0.04); an average number of non-steroidal immunosuppressants and biologic agents (NSIB) (p = 0.04); and a prolonged time to initiation of NSIB (p = 0.01). There were only four patients (3%) who had >0.5+ cells in the anterior chamber. Conclusions: Patients with early-onset BSRC carried a higher risk for anterior segment inflammation, had a more prolonged delay to initiation of treatment with NSIB, and required a greater number of NSIBs to achieve remission.

Original languageEnglish (US)
Pages (from-to)589-595
Number of pages7
JournalOcular Immunology and Inflammation
Volume25
Issue number5
DOIs
StatePublished - Sep 3 2017

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Age of Onset
Biological Factors
Immunosuppressive Agents
Iritis
Anterior Chamber
Cohort Studies
Retrospective Studies
Inflammation
Therapeutics

Keywords

  • Birdshot retinochoroidopathy
  • early-onset
  • inflammation
  • late-onset

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

Cite this

Birdshot Retinochoroidopathy : Differences in Clinical Characteristics between Patients with Early and Late Age of Onset. / Silpa-archa, Sukhum; Cao, Jennifer H.; Boonsopon, Sutasinee; Lee, Joan; Preble, Janine M.; Foster, C. Stephen.

In: Ocular Immunology and Inflammation, Vol. 25, No. 5, 03.09.2017, p. 589-595.

Research output: Contribution to journalArticle

Silpa-archa, Sukhum ; Cao, Jennifer H. ; Boonsopon, Sutasinee ; Lee, Joan ; Preble, Janine M. ; Foster, C. Stephen. / Birdshot Retinochoroidopathy : Differences in Clinical Characteristics between Patients with Early and Late Age of Onset. In: Ocular Immunology and Inflammation. 2017 ; Vol. 25, No. 5. pp. 589-595.
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