Birdshot Retinochoroidopathy: Differences in Clinical Characteristics between Patients with Early and Late Age of Onset

Sukhum Silpa-archa, Jennifer H. Cao, Sutasinee Boonsopon, Joan Lee, Janine M. Preble, C. Stephen Foster

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Purpose: To describe differences in the clinical characteristics of birdshot retinochoroidopathy (BSRC) patients diagnosed early and later in life. Methods: This is a retrospective cohort study. Age was primarily analyzed and 50 years of age at diagnosis was selected as a cut-off point. Results: A total of 144 patients (288 eyes) were included; 68 with early-onset and 76 with late-onset BSRC. The younger group had a statistically significant higher rate of more severe iritis (p = 0.04); an average number of non-steroidal immunosuppressants and biologic agents (NSIB) (p = 0.04); and a prolonged time to initiation of NSIB (p = 0.01). There were only four patients (3%) who had >0.5+ cells in the anterior chamber. Conclusions: Patients with early-onset BSRC carried a higher risk for anterior segment inflammation, had a more prolonged delay to initiation of treatment with NSIB, and required a greater number of NSIBs to achieve remission.

Original languageEnglish (US)
Pages (from-to)589-595
Number of pages7
JournalOcular Immunology and Inflammation
Volume25
Issue number5
DOIs
StatePublished - Sep 3 2017

Keywords

  • Birdshot retinochoroidopathy
  • early-onset
  • inflammation
  • late-onset

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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