Birth Weight and Prematurity in Infants with Single Ventricle Physiology: Pediatric Heart Network Infant Single Ventricle Trial Screened Population

Richard V. Williams, Chitra Ravishankar, Victor Zak, Frank Evans, Andrew M. Atz, William L. Border, Jami Levine, Jennifer S. Li, Lynn Mahony, Seema Mital, Gail D. Pearson, Ashwin Prakash, Daphne T. Hsu

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Objectives: Although congenital heart disease is associated with low birth weight and prematurity, there is little information about these birth outcomes in infants with single ventricle physiology. We describe the birth outcomes (i.e., gestational age and birth weight) in neonates with single ventricle physiology screened for enrollment in the Pediatric Heart Network's Infant Single Ventricle Trial, compare these outcomes with US norms, and examine the association of birth outcomes with anatomic diagnosis and race. Patients and Methods: All neonates with single ventricle physiology presenting to Infant Single Ventricle Trial centers were screened for enrollment. Demographic data and anatomic diagnoses were obtained from medical records. Results: A total of 1245 neonates with single ventricle physiology were screened at 10 centers (63 to 266 per center). Diagnoses included hypoplastic left heart syndrome in 49%, unbalanced atrioventricular septal defect in 12%, and tricuspid atresia in 9%. Preterm birth occurred in 16% of neonates with single ventricle physiology vs. 12% in normal neonates (P < .001), low birth weight (<2.5 kg) in 18% vs. 8% in normals (P < .001), and small for gestational age (<10th percentile by definition) in 22% vs. 10% in normals (P < .001). A genetic syndrome was reported in 8%. The percentage of preterm birth, low birth weight, and small for gestational age was similar between screened neonates with and without hypoplastic left heart syndrome. Conclusions: In this large, contemporary cohort of neonates with single ventricle physiology, rates of preterm birth, low birth weight, and small for gestational age were higher than in the general population, but similar between screened neonates with and without hypoplastic left heart syndrome.

Original languageEnglish (US)
Pages (from-to)96-103
Number of pages8
JournalCongenital Heart Disease
Volume5
Issue number2
DOIs
StatePublished - Mar 1 2010

Keywords

  • Low Birth Weight
  • Preterm Birth
  • Single Ventricle Physiology
  • Small for Gestational Age

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    Williams, R. V., Ravishankar, C., Zak, V., Evans, F., Atz, A. M., Border, W. L., Levine, J., Li, J. S., Mahony, L., Mital, S., Pearson, G. D., Prakash, A., & Hsu, D. T. (2010). Birth Weight and Prematurity in Infants with Single Ventricle Physiology: Pediatric Heart Network Infant Single Ventricle Trial Screened Population. Congenital Heart Disease, 5(2), 96-103. https://doi.org/10.1111/j.1747-0803.2009.00369.x