Bladder neck and urethral erosions after Macroplastique injections

Dayron Rodríguez, Ata Jaffer, Mustafa Hilmy, Philippe Zimmern

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: To evaluate the presentation, risk factors, diagnostic workup, management, and outcomes of Macroplastique (MPQ) erosions. Methods: We performed a retrospective chart review of women experiencing MPQ erosion at two tertiary care centers (United States and United Kingdom). Data collected included age, presenting symptoms, parity, comorbidities, hormone replacement therapy, sexual activity, and smoking status. Previous surgical history, time from MPQ injection, urine culture results, and cystoscopic and imaging findings were also reviewed. Development of stress urinary incontinence (SUI) after MPQ removal and subsequent SUI treatments were recorded. Results: From 2012 to 2018, 18 patients were identified with a median follow-up time of 24 months (interquartile range [IQR] 8-33). All patients presented with recurrent urinary tract infections (rUTI) and had cystoscopic evidence of MPQ erosion. The most common location of erosion was the bladder neck area (72%). Median time to presentation since MPQ injection was 14 months (IQR 11-35). The majority of patients (72%) had a previous history of anti-incontinence surgery. The overall success rate of endoscopic management defined as resolution of presenting symptoms including rUTI was 80%. The majority of patients (80%) developed recurrent SUI following MPQ resection with 33% requiring a subsequent autologous fascial sling placement. Conclusion: MPQ erosions present predominantly with UTI, sometimes years after the original injection, and may necessitate endoscopic management with satisfactory results in most patients. Following excision of MPQ, these patients are highly likely to experience SUI recurrence and need to be appropriately counseled. Some may require additional subsequent autologous fascial sling placement for treatment of their SUI symptoms.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalLUTS: Lower Urinary Tract Symptoms
Volume13
Issue number1
DOIs
StatePublished - Jan 2021

Keywords

  • Macroplastique erosion
  • complications
  • intrinsic sphincter deficiency
  • stress urinary incontinence
  • urethral bulking agent

ASJC Scopus subject areas

  • Neurology
  • Urology

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