TY - JOUR
T1 - Blister fluid cytokines in cutaneous inflammatory bullous disorders
AU - Rhodes, Lesley E.
AU - Hashim, Ibrahim A.
AU - McLaughlin, P. Jeremy
AU - Friedmann, Peter S.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999
Y1 - 1999
N2 - Cytokines are important regulators of immune and inflammatory reactions in the skin, and may contribute to inflammatory blister induction. We examined the profiles of interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) in fluid of spontaneous blisters in the immune-based inflammatory disorders bullous pemphigoid (8 patients), allergic contact dermatitis (5 patients) and toxic epidermal necrolysis (5 patients). These were compared with levels in 9 patients with burns, i.e. inflammatory blisters of non- immune aetiology, and 4 patients with blisters of physical origin. Very high levels of IL-6 were found in bullous pemphigoid and toxic epidermal necrolysis (p<0.001) compared with non-inflammatory and burn blisters. TNF- α levels were high in bullous pemphigoid and burns, but undetectable in non- inflammatory blisters. The pattern in bullous pemphigoid (very high IL-6, high TNF-α) differed subStantially from toxic epidermal necrolysis (very high IL-6, low TNF-α), while burns and allergic contact dermatitis showed lesser elevation of both cytokines. Hence, differences in cytokine profiles were identified, although the relevance to underlying pathomechanisms is uncertain.
AB - Cytokines are important regulators of immune and inflammatory reactions in the skin, and may contribute to inflammatory blister induction. We examined the profiles of interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) in fluid of spontaneous blisters in the immune-based inflammatory disorders bullous pemphigoid (8 patients), allergic contact dermatitis (5 patients) and toxic epidermal necrolysis (5 patients). These were compared with levels in 9 patients with burns, i.e. inflammatory blisters of non- immune aetiology, and 4 patients with blisters of physical origin. Very high levels of IL-6 were found in bullous pemphigoid and toxic epidermal necrolysis (p<0.001) compared with non-inflammatory and burn blisters. TNF- α levels were high in bullous pemphigoid and burns, but undetectable in non- inflammatory blisters. The pattern in bullous pemphigoid (very high IL-6, high TNF-α) differed subStantially from toxic epidermal necrolysis (very high IL-6, low TNF-α), while burns and allergic contact dermatitis showed lesser elevation of both cytokines. Hence, differences in cytokine profiles were identified, although the relevance to underlying pathomechanisms is uncertain.
KW - Blister formation
KW - Interleukin-6
KW - Tumour necrosis factor-α
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U2 - 10.1080/000155599750010689
DO - 10.1080/000155599750010689
M3 - Article
C2 - 10429986
AN - SCOPUS:0033006538
SN - 0001-5555
VL - 79
SP - 288
EP - 290
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
IS - 4
ER -