Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice

C. L. Arteaga, L. J. Kitten, E. B. Coronado, S. Jacobs, F. C. Kull, D. C. Allred, C. K. Osborne

Research output: Contribution to journalArticle

287 Scopus citations

Abstract

Insulin and insulin-like growth factors (IGFs) stimulate the growth of human breast cancer cells in vitro. The type I somatomedin receptor (SR) expressed in these cells may mediate the growth effects of these peptides. We have examined the role of this receptor on human breast cancer growth with a monoclonal antibody (α-IR-3) that blocks the receptor binding domain and inhibits IGF-I-induced growth. α-IR-3 inhibited clonal growth in vitro and blocked the mitogenic effect of exogenous IGF-I in both MCF-7 and MDA-231 breast cancer cell lines. Antibody-induced blockade of the type I SR also inhibited the estrogen-independent MDA-231 cells growing in vivo in nude mice, but growth of the estrogen-dependent MCF-7 cells was unaffected. IGFs are important growth regulators of MDA-231 breast cancer cells. Blockade of this growth stimulatory pathway may provide a new treatment strategy.

Original languageEnglish (US)
Pages (from-to)1418-1423
Number of pages6
JournalJournal of Clinical Investigation
Volume84
Issue number5
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Medicine(all)

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