TY - JOUR
T1 - Blood- and tissue-based biomarkers for prediction of outcomes in urothelial carcinoma of the bladder
AU - Xylinas, Evanguelos
AU - Kluth, Luis A.
AU - Lotan, Yair
AU - Daneshmand, Siamak
AU - Rieken, Malte
AU - Karakiewicz, Pierre I.
AU - Shariat, Shahrokh F.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/4
Y1 - 2014/4
N2 - Objectives: Urothelial carcinoma of the bladder (UCB) is a highly heterogeneous malignancy that causes significant morbidity and mortality. Standard pathologic features (stage, grade, and nodal status) are insufficient to predict accurately a patient's outcome. Biomarkers could help clinicians provide individualized prognostications and allow risk-stratified clinical decision making regarding surgical and medical treatment. This review summarizes the existing tissue- and blood-based biomarkers in UCB. Material and methods: A PubMed/Medline search was conducted to identify original articles regarding molecular biomarkers and UCB. Searches were limited to papers published in English. Keywords included urothelial carcinoma, bladder cancer, transitional cell, biomarker, marker, staining, cystectomy, recurrence or progression, survival, prediction, and prognosis. Results: The articles with the highest level of evidence were selected and reviewed, with the consensus of all the authors of this paper. Conclusions: There is no doubt that a panel of biomarkers would eventually improve our clinical decision making regarding treatment and follow-up. However, to date, no biomarker panel is yet validated for daily clinical practice.
AB - Objectives: Urothelial carcinoma of the bladder (UCB) is a highly heterogeneous malignancy that causes significant morbidity and mortality. Standard pathologic features (stage, grade, and nodal status) are insufficient to predict accurately a patient's outcome. Biomarkers could help clinicians provide individualized prognostications and allow risk-stratified clinical decision making regarding surgical and medical treatment. This review summarizes the existing tissue- and blood-based biomarkers in UCB. Material and methods: A PubMed/Medline search was conducted to identify original articles regarding molecular biomarkers and UCB. Searches were limited to papers published in English. Keywords included urothelial carcinoma, bladder cancer, transitional cell, biomarker, marker, staining, cystectomy, recurrence or progression, survival, prediction, and prognosis. Results: The articles with the highest level of evidence were selected and reviewed, with the consensus of all the authors of this paper. Conclusions: There is no doubt that a panel of biomarkers would eventually improve our clinical decision making regarding treatment and follow-up. However, to date, no biomarker panel is yet validated for daily clinical practice.
KW - Biomarker
KW - Bladder cancer
KW - Blood-based
KW - Molecular marker
KW - Prediction
KW - Prognosis
KW - Survival
KW - Tissue-based
KW - Urothelial carcinoma
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U2 - 10.1016/j.urolonc.2013.06.009
DO - 10.1016/j.urolonc.2013.06.009
M3 - Article
C2 - 24332648
AN - SCOPUS:84897073946
SN - 1078-1439
VL - 32
SP - 230
EP - 242
JO - Urologic Oncology: Seminars and Original Investigations
JF - Urologic Oncology: Seminars and Original Investigations
IS - 3
ER -