Abstract
Blood-based bioenergetic profiling has promising applications as a minimally invasive biomarker of systemic bioenergetic capacity. In the present study, we examined peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a cohort of African Americans with long-standing Type 2 diabetes. Key parameters of PBMC respiration were correlated with white matter, gray matter, and total intracranial volumes. Our analyses indicate that these relationships are primarily driven by the relationship of systemic bioenergetic capacity with total intracranial volume, suggesting that systemic differences in mitochondrial function may play a role in overall brain morphology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2509-2518 |
| Number of pages | 10 |
| Journal | Clinical Science |
| Volume | 132 |
| Issue number | 23 |
| DOIs | |
| State | Published - Dec 1 2018 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes. / Mahapatra, Gargi; Smith, S. Carrie; Hughes, Timothy M.; Wagner, Benjamin; Maldjian, Joseph A; Freedman, Barry I.; Molina, Anthony J.A.
In: Clinical Science, Vol. 132, No. 23, 01.12.2018, p. 2509-2518.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes
AU - Mahapatra, Gargi
AU - Smith, S. Carrie
AU - Hughes, Timothy M.
AU - Wagner, Benjamin
AU - Maldjian, Joseph A
AU - Freedman, Barry I.
AU - Molina, Anthony J.A.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Blood-based bioenergetic profiling has promising applications as a minimally invasive biomarker of systemic bioenergetic capacity. In the present study, we examined peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a cohort of African Americans with long-standing Type 2 diabetes. Key parameters of PBMC respiration were correlated with white matter, gray matter, and total intracranial volumes. Our analyses indicate that these relationships are primarily driven by the relationship of systemic bioenergetic capacity with total intracranial volume, suggesting that systemic differences in mitochondrial function may play a role in overall brain morphology.
AB - Blood-based bioenergetic profiling has promising applications as a minimally invasive biomarker of systemic bioenergetic capacity. In the present study, we examined peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a cohort of African Americans with long-standing Type 2 diabetes. Key parameters of PBMC respiration were correlated with white matter, gray matter, and total intracranial volumes. Our analyses indicate that these relationships are primarily driven by the relationship of systemic bioenergetic capacity with total intracranial volume, suggesting that systemic differences in mitochondrial function may play a role in overall brain morphology.
UR - http://www.scopus.com/inward/record.url?scp=85058791580&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058791580&partnerID=8YFLogxK
U2 - 10.1042/CS20180690
DO - 10.1042/CS20180690
M3 - Article
C2 - 30401689
AN - SCOPUS:85058791580
VL - 132
SP - 2509
EP - 2518
JO - Clinical Science
JF - Clinical Science
SN - 0143-5221
IS - 23
ER -