@article{544b1d171a1f4188ac9b678d8cb4bfbe,
title = "Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes",
abstract = "Blood-based bioenergetic profiling has promising applications as a minimally invasive biomarker of systemic bioenergetic capacity. In the present study, we examined peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a cohort of African Americans with long-standing Type 2 diabetes. Key parameters of PBMC respiration were correlated with white matter, gray matter, and total intracranial volumes. Our analyses indicate that these relationships are primarily driven by the relationship of systemic bioenergetic capacity with total intracranial volume, suggesting that systemic differences in mitochondrial function may play a role in overall brain morphology.",
author = "Gargi Mahapatra and Smith, {S. Carrie} and Hughes, {Timothy M.} and Benjamin Wagner and Maldjian, {Joseph A} and Freedman, {Barry I.} and Molina, {Anthony J.A.}",
note = "Funding Information: National Institutes of Health/National Institute on Aging [R01 AG054523 (to A.J.A.M.)]; National Institutes of Health/National Institute on Aging [R21 AG051077 (to A.J.A.M)]; American Heart Association [15MCPRP25680019 (to A.J.A.M)]; National Iinstitutes of Health/National Institute of Neurological Disorders and Stroke [NS075107 (to B.I.F.)]; Wake Forest School of Medicine Pepper Center [P30 AG21332]; and Wake Forest School of Medicine Alzheimer's Disease Research Center [P30 AG049638].",
year = "2018",
month = dec,
day = "1",
doi = "10.1042/CS20180690",
language = "English (US)",
volume = "132",
pages = "2509--2518",
journal = "Clinical Science",
issn = "0143-5221",
publisher = "Portland Press Ltd.",
number = "23",
}