Blood Induction and Embryonic Formation

Xiaoying Bai, Leonard I. Zon

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Vertebrate blood derives from mesoderm. Blood formation (hematopoiesis) occurs in successive waves. The primitive wave predominantly generates red cells to transiently provide oxygen for the rapidly growing embryo. The definitive wave produces hematopoietic stem cells (HSCs) that ultimately differentiate into all the blood lineages in the adult. Hematopoiesis is tightly regulated by complex interactions between extrinsic and intrinsic factors. Transcription factors play intrinsic roles to define HSC generation and lineage differentiation. The process of hematopoiesis is highly conserved throughout vertebrate evolution. The genetic manipulation of animal models, such as mouse and zebrafish, has identified many essential genes controlling normal and malignant hematopoiesis.

Original languageEnglish (US)
Title of host publicationPrinciples of Developmental Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages451-467
Number of pages17
ISBN (Print)9780124059450
DOIs
StatePublished - Jan 1 2015

Keywords

  • Bone marrow transplantation
  • HSC
  • Hemangioblast
  • Hematopoiesis
  • Hemogenic endothelium

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Bai, X., & Zon, L. I. (2015). Blood Induction and Embryonic Formation. In Principles of Developmental Genetics: Second Edition (pp. 451-467). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-405945-0.00025-9