Blood viscosity, plasma adrenaline and fasting insulin in hypertensive patients with left ventricular hypertrophy: ICARUS, a LIFE substudy

Aud Høieggen, Eigil Fossum, Shawna D. Nesbitt, Vittorio Palmieri, Sverre E. Kjeldsen, Merete Bakken Molvig, Agathe Nueland

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We have seen relationships between whole blood viscosity (WBV) and components of the metabolic cardiovascular syndrome in borderline hypertensive young men and suggested that sympathetic nervous system (SNS) activity may be a mediator. In the present study we aimed to test this hypothesis in established hypertension and to investigate the relationship between WBV and cardiac dimensions. Unmedicated patients (n = 42) with stage II-III hypertension and electrocardiographic left ventricular hypertrophy (LVH) underwent hyperinsulinemic isoglycemic glucose clamp to assess glucose disposal rate (GDR) and echocardiographic studies. WBV, plasma catecholamines and insulin were measured in arterialized venous blood. WBV at high shear rate correlated with baseline plasma adrenaline (r = 0.33, p = 0.04) and fasting insulin (r = 0.34, p = 0.04) while there was a negative trend for GDR (r = -0.21, p = 0.2). WBV at low shear rate correlated with plasma adrenaline (r = 0.49, p = 0.002) and resting heart rate (r = 0.36, p = 0.02). WBV was higher in smokers than in non-smokers (p = 0.02) and in males than in females (p = 0.02). Fasting insulin independently explained 12% of the variation in WBV at high shear, while baseline adrenaline independently explained 17% of the variation in WBV at low shear. Systolic blood pressure explained 31% of the variation in LV mass index. Thus, we demonstrate positive relationships between blood viscosity versus plasma adrenaline and fasting insulin in hypertensive patients with LVH. We suggest that adrenergic activity may increase hematocrit and viscosity and hence reduce insulin sensitivity.

Original languageEnglish (US)
Pages (from-to)83-90
Number of pages8
JournalBlood Pressure
Volume9
Issue number2-3
StatePublished - 2000

Fingerprint

Blood Viscosity
Left Ventricular Hypertrophy
Epinephrine
Fasting
Insulin
Metabolic Syndrome X
Blood Pressure
Hypertension
Glucose
Glucose Clamp Technique
Sympathetic Nervous System
Hematocrit
Viscosity
Adrenergic Agents
Catecholamines
Insulin Resistance
Heart Rate

Keywords

  • Hypertension
  • Insulin resistance
  • Plasma adrenaline
  • Sympathetic nervous system activity
  • Whole blood viscosity

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Høieggen, A., Fossum, E., Nesbitt, S. D., Palmieri, V., Kjeldsen, S. E., Molvig, M. B., & Nueland, A. (2000). Blood viscosity, plasma adrenaline and fasting insulin in hypertensive patients with left ventricular hypertrophy: ICARUS, a LIFE substudy. Blood Pressure, 9(2-3), 83-90.

Blood viscosity, plasma adrenaline and fasting insulin in hypertensive patients with left ventricular hypertrophy : ICARUS, a LIFE substudy. / Høieggen, Aud; Fossum, Eigil; Nesbitt, Shawna D.; Palmieri, Vittorio; Kjeldsen, Sverre E.; Molvig, Merete Bakken; Nueland, Agathe.

In: Blood Pressure, Vol. 9, No. 2-3, 2000, p. 83-90.

Research output: Contribution to journalArticle

Høieggen, A, Fossum, E, Nesbitt, SD, Palmieri, V, Kjeldsen, SE, Molvig, MB & Nueland, A 2000, 'Blood viscosity, plasma adrenaline and fasting insulin in hypertensive patients with left ventricular hypertrophy: ICARUS, a LIFE substudy', Blood Pressure, vol. 9, no. 2-3, pp. 83-90.
Høieggen, Aud ; Fossum, Eigil ; Nesbitt, Shawna D. ; Palmieri, Vittorio ; Kjeldsen, Sverre E. ; Molvig, Merete Bakken ; Nueland, Agathe. / Blood viscosity, plasma adrenaline and fasting insulin in hypertensive patients with left ventricular hypertrophy : ICARUS, a LIFE substudy. In: Blood Pressure. 2000 ; Vol. 9, No. 2-3. pp. 83-90.
@article{25affcc201ed4023b1b950d630929288,
title = "Blood viscosity, plasma adrenaline and fasting insulin in hypertensive patients with left ventricular hypertrophy: ICARUS, a LIFE substudy",
abstract = "We have seen relationships between whole blood viscosity (WBV) and components of the metabolic cardiovascular syndrome in borderline hypertensive young men and suggested that sympathetic nervous system (SNS) activity may be a mediator. In the present study we aimed to test this hypothesis in established hypertension and to investigate the relationship between WBV and cardiac dimensions. Unmedicated patients (n = 42) with stage II-III hypertension and electrocardiographic left ventricular hypertrophy (LVH) underwent hyperinsulinemic isoglycemic glucose clamp to assess glucose disposal rate (GDR) and echocardiographic studies. WBV, plasma catecholamines and insulin were measured in arterialized venous blood. WBV at high shear rate correlated with baseline plasma adrenaline (r = 0.33, p = 0.04) and fasting insulin (r = 0.34, p = 0.04) while there was a negative trend for GDR (r = -0.21, p = 0.2). WBV at low shear rate correlated with plasma adrenaline (r = 0.49, p = 0.002) and resting heart rate (r = 0.36, p = 0.02). WBV was higher in smokers than in non-smokers (p = 0.02) and in males than in females (p = 0.02). Fasting insulin independently explained 12{\%} of the variation in WBV at high shear, while baseline adrenaline independently explained 17{\%} of the variation in WBV at low shear. Systolic blood pressure explained 31{\%} of the variation in LV mass index. Thus, we demonstrate positive relationships between blood viscosity versus plasma adrenaline and fasting insulin in hypertensive patients with LVH. We suggest that adrenergic activity may increase hematocrit and viscosity and hence reduce insulin sensitivity.",
keywords = "Hypertension, Insulin resistance, Plasma adrenaline, Sympathetic nervous system activity, Whole blood viscosity",
author = "Aud H{\o}ieggen and Eigil Fossum and Nesbitt, {Shawna D.} and Vittorio Palmieri and Kjeldsen, {Sverre E.} and Molvig, {Merete Bakken} and Agathe Nueland",
year = "2000",
language = "English (US)",
volume = "9",
pages = "83--90",
journal = "Blood Pressure",
issn = "0803-7051",
publisher = "Informa Healthcare",
number = "2-3",

}

TY - JOUR

T1 - Blood viscosity, plasma adrenaline and fasting insulin in hypertensive patients with left ventricular hypertrophy

T2 - ICARUS, a LIFE substudy

AU - Høieggen, Aud

AU - Fossum, Eigil

AU - Nesbitt, Shawna D.

AU - Palmieri, Vittorio

AU - Kjeldsen, Sverre E.

AU - Molvig, Merete Bakken

AU - Nueland, Agathe

PY - 2000

Y1 - 2000

N2 - We have seen relationships between whole blood viscosity (WBV) and components of the metabolic cardiovascular syndrome in borderline hypertensive young men and suggested that sympathetic nervous system (SNS) activity may be a mediator. In the present study we aimed to test this hypothesis in established hypertension and to investigate the relationship between WBV and cardiac dimensions. Unmedicated patients (n = 42) with stage II-III hypertension and electrocardiographic left ventricular hypertrophy (LVH) underwent hyperinsulinemic isoglycemic glucose clamp to assess glucose disposal rate (GDR) and echocardiographic studies. WBV, plasma catecholamines and insulin were measured in arterialized venous blood. WBV at high shear rate correlated with baseline plasma adrenaline (r = 0.33, p = 0.04) and fasting insulin (r = 0.34, p = 0.04) while there was a negative trend for GDR (r = -0.21, p = 0.2). WBV at low shear rate correlated with plasma adrenaline (r = 0.49, p = 0.002) and resting heart rate (r = 0.36, p = 0.02). WBV was higher in smokers than in non-smokers (p = 0.02) and in males than in females (p = 0.02). Fasting insulin independently explained 12% of the variation in WBV at high shear, while baseline adrenaline independently explained 17% of the variation in WBV at low shear. Systolic blood pressure explained 31% of the variation in LV mass index. Thus, we demonstrate positive relationships between blood viscosity versus plasma adrenaline and fasting insulin in hypertensive patients with LVH. We suggest that adrenergic activity may increase hematocrit and viscosity and hence reduce insulin sensitivity.

AB - We have seen relationships between whole blood viscosity (WBV) and components of the metabolic cardiovascular syndrome in borderline hypertensive young men and suggested that sympathetic nervous system (SNS) activity may be a mediator. In the present study we aimed to test this hypothesis in established hypertension and to investigate the relationship between WBV and cardiac dimensions. Unmedicated patients (n = 42) with stage II-III hypertension and electrocardiographic left ventricular hypertrophy (LVH) underwent hyperinsulinemic isoglycemic glucose clamp to assess glucose disposal rate (GDR) and echocardiographic studies. WBV, plasma catecholamines and insulin were measured in arterialized venous blood. WBV at high shear rate correlated with baseline plasma adrenaline (r = 0.33, p = 0.04) and fasting insulin (r = 0.34, p = 0.04) while there was a negative trend for GDR (r = -0.21, p = 0.2). WBV at low shear rate correlated with plasma adrenaline (r = 0.49, p = 0.002) and resting heart rate (r = 0.36, p = 0.02). WBV was higher in smokers than in non-smokers (p = 0.02) and in males than in females (p = 0.02). Fasting insulin independently explained 12% of the variation in WBV at high shear, while baseline adrenaline independently explained 17% of the variation in WBV at low shear. Systolic blood pressure explained 31% of the variation in LV mass index. Thus, we demonstrate positive relationships between blood viscosity versus plasma adrenaline and fasting insulin in hypertensive patients with LVH. We suggest that adrenergic activity may increase hematocrit and viscosity and hence reduce insulin sensitivity.

KW - Hypertension

KW - Insulin resistance

KW - Plasma adrenaline

KW - Sympathetic nervous system activity

KW - Whole blood viscosity

UR - http://www.scopus.com/inward/record.url?scp=0034129874&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034129874&partnerID=8YFLogxK

M3 - Article

C2 - 10855729

AN - SCOPUS:0034129874

VL - 9

SP - 83

EP - 90

JO - Blood Pressure

JF - Blood Pressure

SN - 0803-7051

IS - 2-3

ER -