Blood volume and extracellular fluid volume during administration of ACTH and cortisone

Mackenzie Walser, Donald W. Seldin, Charles H. Burnett

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effects of cortisone and ACTH on blood and extracellular fluid volumes have been studied in normotensive subjects without renal or cardiac disease, under conditions of (1) salt restriction and (2) controlled salt intake. When salt was restricted, blood volume did not change significantly but the volume of fluid available for dilution of radiosulfate increased slightly, the increment being derived from internal sources. When salt was supplied, extracellular fluid expanded considerably but venous pressure and plasma protein concentration did not change significantly. Blood and plasma volume remained constant or fell slightly as extracellular fluid volume expanded, and failed to reflect day-to-day fluctuations in the interstitial space. The stimulus which promotes renal adjustment to an excess of interstitial fluid apparently need not involve blood volume, venous pressure or plasma oncotic pressure.

Original languageEnglish (US)
Pages (from-to)454-461
Number of pages8
JournalThe American journal of medicine
Volume18
Issue number3
StatePublished - Mar 1955

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Cortisone
Extracellular Fluid
Blood Volume
Adrenocorticotropic Hormone
Salts
Venous Pressure
Kidney
Plasma Volume
Blood Proteins
Heart Diseases
Pressure

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Blood volume and extracellular fluid volume during administration of ACTH and cortisone. / Walser, Mackenzie; Seldin, Donald W.; Burnett, Charles H.

In: The American journal of medicine, Vol. 18, No. 3, 03.1955, p. 454-461.

Research output: Contribution to journalArticle

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