BMD measurement by DXA method in useful for estimation of bone strength of lumbar vertebra in CKD-MBD model rats

Ken Kunimoto, Kazuhiro Shiizaki, Fumie Saji, Yoshiyuki Hanba, Toshifumi Sakaguchi, Shigeo Negi, Tadao Akizawa, Takashi Shigematsu

Research output: Contribution to journalArticle

Abstract

In patients with chronic renal failure, especially patients receiving continuous hemodialysis, the risk of fracture increases as Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) advances. In hemodialysis patients, bone fracture is a serious issue because it leads to decreased Activities of Daily Living (ADL) and associated increases in medical expenses and mortality risk. We usually measure Bone Mineral Density (BMD) in order to estimate the fracture risk, but there is no certain consensus as to which part of the bone should we measure. Also, the relationship between decreased BMD and lowered bone strength has not established yet. To resolve those issues, the femur and lumbar vertebra were harvested from renal failure rats with controlled Parathyroid Hormone (PTH) levels, and their BMD and bone strength were measured directly. There was significant positive correlation between the lumbar vertebra BMD and femur BMD (r = 0.51, P = 0.002). This result indicates that BMD in other areas could be estimated from any specific area. In all rats, the BMD reflected the lumbar vertebra bone strength independently of the area measured (r = 0.51, P = 0.0007 vs L2-4 BMD; r = 0.40, P = 0.018 vs femur BMD) but did not reflect the bone strength of the femur. The present study showed that the relationship between BMD and bone strength obviously existed in lumbar vertebra, the effect of bone metabolism was reflected earlier and BMD measurement using the Dual energy X-ray Absoptiometry (DXA) method was useful for determining lumbar bone strength.

Original languageEnglish (US)
Pages (from-to)136-142
Number of pages7
JournalJournal of the Wakayama Medical Society
Volume60
Issue number4
StatePublished - Dec 2009

Fingerprint

Chronic Kidney Disease-Mineral and Bone Disorder
Lumbar Vertebrae
Bone Density
X-Rays
Bone and Bones
Femur
Renal Dialysis
Bone Fractures
Activities of Daily Living
Parathyroid Hormone
Chronic Kidney Failure
Renal Insufficiency

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kunimoto, K., Shiizaki, K., Saji, F., Hanba, Y., Sakaguchi, T., Negi, S., ... Shigematsu, T. (2009). BMD measurement by DXA method in useful for estimation of bone strength of lumbar vertebra in CKD-MBD model rats. Journal of the Wakayama Medical Society, 60(4), 136-142.

BMD measurement by DXA method in useful for estimation of bone strength of lumbar vertebra in CKD-MBD model rats. / Kunimoto, Ken; Shiizaki, Kazuhiro; Saji, Fumie; Hanba, Yoshiyuki; Sakaguchi, Toshifumi; Negi, Shigeo; Akizawa, Tadao; Shigematsu, Takashi.

In: Journal of the Wakayama Medical Society, Vol. 60, No. 4, 12.2009, p. 136-142.

Research output: Contribution to journalArticle

Kunimoto, K, Shiizaki, K, Saji, F, Hanba, Y, Sakaguchi, T, Negi, S, Akizawa, T & Shigematsu, T 2009, 'BMD measurement by DXA method in useful for estimation of bone strength of lumbar vertebra in CKD-MBD model rats', Journal of the Wakayama Medical Society, vol. 60, no. 4, pp. 136-142.
Kunimoto, Ken ; Shiizaki, Kazuhiro ; Saji, Fumie ; Hanba, Yoshiyuki ; Sakaguchi, Toshifumi ; Negi, Shigeo ; Akizawa, Tadao ; Shigematsu, Takashi. / BMD measurement by DXA method in useful for estimation of bone strength of lumbar vertebra in CKD-MBD model rats. In: Journal of the Wakayama Medical Society. 2009 ; Vol. 60, No. 4. pp. 136-142.
@article{5a451d6dc4ee4548a11b742a661a34f1,
title = "BMD measurement by DXA method in useful for estimation of bone strength of lumbar vertebra in CKD-MBD model rats",
abstract = "In patients with chronic renal failure, especially patients receiving continuous hemodialysis, the risk of fracture increases as Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) advances. In hemodialysis patients, bone fracture is a serious issue because it leads to decreased Activities of Daily Living (ADL) and associated increases in medical expenses and mortality risk. We usually measure Bone Mineral Density (BMD) in order to estimate the fracture risk, but there is no certain consensus as to which part of the bone should we measure. Also, the relationship between decreased BMD and lowered bone strength has not established yet. To resolve those issues, the femur and lumbar vertebra were harvested from renal failure rats with controlled Parathyroid Hormone (PTH) levels, and their BMD and bone strength were measured directly. There was significant positive correlation between the lumbar vertebra BMD and femur BMD (r = 0.51, P = 0.002). This result indicates that BMD in other areas could be estimated from any specific area. In all rats, the BMD reflected the lumbar vertebra bone strength independently of the area measured (r = 0.51, P = 0.0007 vs L2-4 BMD; r = 0.40, P = 0.018 vs femur BMD) but did not reflect the bone strength of the femur. The present study showed that the relationship between BMD and bone strength obviously existed in lumbar vertebra, the effect of bone metabolism was reflected earlier and BMD measurement using the Dual energy X-ray Absoptiometry (DXA) method was useful for determining lumbar bone strength.",
author = "Ken Kunimoto and Kazuhiro Shiizaki and Fumie Saji and Yoshiyuki Hanba and Toshifumi Sakaguchi and Shigeo Negi and Tadao Akizawa and Takashi Shigematsu",
year = "2009",
month = "12",
language = "English (US)",
volume = "60",
pages = "136--142",
journal = "Journal of the Wakayama Medical Society",
issn = "0043-0013",
publisher = "Wakayama Medical Society",
number = "4",

}

TY - JOUR

T1 - BMD measurement by DXA method in useful for estimation of bone strength of lumbar vertebra in CKD-MBD model rats

AU - Kunimoto, Ken

AU - Shiizaki, Kazuhiro

AU - Saji, Fumie

AU - Hanba, Yoshiyuki

AU - Sakaguchi, Toshifumi

AU - Negi, Shigeo

AU - Akizawa, Tadao

AU - Shigematsu, Takashi

PY - 2009/12

Y1 - 2009/12

N2 - In patients with chronic renal failure, especially patients receiving continuous hemodialysis, the risk of fracture increases as Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) advances. In hemodialysis patients, bone fracture is a serious issue because it leads to decreased Activities of Daily Living (ADL) and associated increases in medical expenses and mortality risk. We usually measure Bone Mineral Density (BMD) in order to estimate the fracture risk, but there is no certain consensus as to which part of the bone should we measure. Also, the relationship between decreased BMD and lowered bone strength has not established yet. To resolve those issues, the femur and lumbar vertebra were harvested from renal failure rats with controlled Parathyroid Hormone (PTH) levels, and their BMD and bone strength were measured directly. There was significant positive correlation between the lumbar vertebra BMD and femur BMD (r = 0.51, P = 0.002). This result indicates that BMD in other areas could be estimated from any specific area. In all rats, the BMD reflected the lumbar vertebra bone strength independently of the area measured (r = 0.51, P = 0.0007 vs L2-4 BMD; r = 0.40, P = 0.018 vs femur BMD) but did not reflect the bone strength of the femur. The present study showed that the relationship between BMD and bone strength obviously existed in lumbar vertebra, the effect of bone metabolism was reflected earlier and BMD measurement using the Dual energy X-ray Absoptiometry (DXA) method was useful for determining lumbar bone strength.

AB - In patients with chronic renal failure, especially patients receiving continuous hemodialysis, the risk of fracture increases as Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) advances. In hemodialysis patients, bone fracture is a serious issue because it leads to decreased Activities of Daily Living (ADL) and associated increases in medical expenses and mortality risk. We usually measure Bone Mineral Density (BMD) in order to estimate the fracture risk, but there is no certain consensus as to which part of the bone should we measure. Also, the relationship between decreased BMD and lowered bone strength has not established yet. To resolve those issues, the femur and lumbar vertebra were harvested from renal failure rats with controlled Parathyroid Hormone (PTH) levels, and their BMD and bone strength were measured directly. There was significant positive correlation between the lumbar vertebra BMD and femur BMD (r = 0.51, P = 0.002). This result indicates that BMD in other areas could be estimated from any specific area. In all rats, the BMD reflected the lumbar vertebra bone strength independently of the area measured (r = 0.51, P = 0.0007 vs L2-4 BMD; r = 0.40, P = 0.018 vs femur BMD) but did not reflect the bone strength of the femur. The present study showed that the relationship between BMD and bone strength obviously existed in lumbar vertebra, the effect of bone metabolism was reflected earlier and BMD measurement using the Dual energy X-ray Absoptiometry (DXA) method was useful for determining lumbar bone strength.

UR - http://www.scopus.com/inward/record.url?scp=84876403265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876403265&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84876403265

VL - 60

SP - 136

EP - 142

JO - Journal of the Wakayama Medical Society

JF - Journal of the Wakayama Medical Society

SN - 0043-0013

IS - 4

ER -