Bmi1, stem cells, and senescence regulation

In Kyung Park; Sean J. Morrison; Michael F. Clarke

doi:10.1172/JCI200420800

Bmi1, stem cells, and senescence regulation

In Kyung Park, Sean J. Morrison, Michael F. Clarke

Research output: Contribution to journal › Review article › peer-review

443 Scopus citations

Abstract

Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms. Therefore, senescence of stem cells must be prevented. Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death.

Original language	English (US)
Pages (from-to)	175-179
Number of pages	5
Journal	Journal of Clinical Investigation
Volume	113
Issue number	2
DOIs	https://doi.org/10.1172/JCI200420800
State	Published - Jan 2004

ASJC Scopus subject areas

General Medicine

Access to Document

10.1172/JCI200420800

Cite this

@article{078b9618eb3947918495a831701ce4b9,

title = "Bmi1, stem cells, and senescence regulation",

abstract = "Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms. Therefore, senescence of stem cells must be prevented. Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death.",

author = "Park, {In Kyung} and Morrison, {Sean J.} and Clarke, {Michael F.}",

year = "2004",

month = jan,

doi = "10.1172/JCI200420800",

language = "English (US)",

volume = "113",

pages = "175--179",

journal = "Journal of Clinical Investigation",

issn = "0021-9738",

publisher = "The American Society for Clinical Investigation",

number = "2",

}

TY - JOUR

T1 - Bmi1, stem cells, and senescence regulation

AU - Park, In Kyung

AU - Morrison, Sean J.

AU - Clarke, Michael F.

PY - 2004/1

Y1 - 2004/1

N2 - Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms. Therefore, senescence of stem cells must be prevented. Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death.

AB - Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms. Therefore, senescence of stem cells must be prevented. Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death.

UR - http://www.scopus.com/inward/record.url?scp=1342289563&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1342289563&partnerID=8YFLogxK

U2 - 10.1172/JCI200420800

DO - 10.1172/JCI200420800

M3 - Review article

C2 - 14722607

AN - SCOPUS:1342289563

SN - 0021-9738

VL - 113

SP - 175

EP - 179

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 2

ER -

Bmi1, stem cells, and senescence regulation

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this