Bmi1, stem cells, and senescence regulation

In Kyung Park, Sean J. Morrison, Michael F. Clarke

Research output: Contribution to journalReview article

377 Scopus citations

Abstract

Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms. Therefore, senescence of stem cells must be prevented. Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalJournal of Clinical Investigation
Volume113
Issue number2
DOIs
StatePublished - Jan 1 2004

ASJC Scopus subject areas

  • Medicine(all)

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