BMP-2-induced bone formation and neural inflammation

Vi Nguyen, Carolyn A. Meyers, Noah Yan, Shailesh Agarwal, Benjamin Levi, Aaron W. James

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Bone morphogenetic protein-2 (BMP-2), a potent osteoinductive cytokine from the transforming growth factor beta (TGF-β) family, is currently the most commonly used protein-based bone graft substitute. Although clinical use of BMP-2 has significantly increased in recent years, its prominence has also highlighted various adverse events, including induction of inflammation. This review will elucidate the relationship between BMP-2 and inflammation, with an emphasis on peripheral nerve inflammation and its sequelae. As well, we review the potential additive roles of nerve released factors with BMP2 in the context of bone formation.

Original languageEnglish (US)
Pages (from-to)252-256
Number of pages5
JournalJournal of Orthopaedics
Volume14
Issue number2
DOIs
StatePublished - Jun 1 2017
Externally publishedYes

Keywords

  • Bone morphogenetic protein
  • Inflammation
  • Neural inflammation
  • Neuritis
  • Osteogenesis
  • Skeletal engineering

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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