BMP-2-induced bone formation and neural inflammation

Vi Nguyen; Carolyn A. Meyers; Noah Yan; Shailesh Agarwal; Benjamin Levi; Aaron W. James

doi:10.1016/j.jor.2017.03.003

BMP-2-induced bone formation and neural inflammation

Vi Nguyen, Carolyn A. Meyers, Noah Yan, Shailesh Agarwal, Benjamin Levi, Aaron W. James

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Abstract

Bone morphogenetic protein-2 (BMP-2), a potent osteoinductive cytokine from the transforming growth factor beta (TGF-β) family, is currently the most commonly used protein-based bone graft substitute. Although clinical use of BMP-2 has significantly increased in recent years, its prominence has also highlighted various adverse events, including induction of inflammation. This review will elucidate the relationship between BMP-2 and inflammation, with an emphasis on peripheral nerve inflammation and its sequelae. As well, we review the potential additive roles of nerve released factors with BMP2 in the context of bone formation.

Original language	English (US)
Pages (from-to)	252-256
Number of pages	5
Journal	Journal of Orthopaedics
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/j.jor.2017.03.003
State	Published - Jun 1 2017
Externally published	Yes

Keywords

Bone morphogenetic protein
Inflammation
Neural inflammation
Neuritis
Osteogenesis
Skeletal engineering

ASJC Scopus subject areas

Orthopedics and Sports Medicine

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10.1016/j.jor.2017.03.003

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title = "BMP-2-induced bone formation and neural inflammation",

abstract = "Bone morphogenetic protein-2 (BMP-2), a potent osteoinductive cytokine from the transforming growth factor beta (TGF-β) family, is currently the most commonly used protein-based bone graft substitute. Although clinical use of BMP-2 has significantly increased in recent years, its prominence has also highlighted various adverse events, including induction of inflammation. This review will elucidate the relationship between BMP-2 and inflammation, with an emphasis on peripheral nerve inflammation and its sequelae. As well, we review the potential additive roles of nerve released factors with BMP2 in the context of bone formation.",

keywords = "Bone morphogenetic protein, Inflammation, Neural inflammation, Neuritis, Osteogenesis, Skeletal engineering",

author = "Vi Nguyen and Meyers, {Carolyn A.} and Noah Yan and Shailesh Agarwal and Benjamin Levi and James, {Aaron W.}",

note = "Publisher Copyright: {\textcopyright} 2017 Prof. PK Surendran Memorial Education Foundation",

year = "2017",

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doi = "10.1016/j.jor.2017.03.003",

language = "English (US)",

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T1 - BMP-2-induced bone formation and neural inflammation

AU - Nguyen, Vi

AU - Meyers, Carolyn A.

AU - Yan, Noah

AU - Agarwal, Shailesh

AU - Levi, Benjamin

AU - James, Aaron W.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Bone morphogenetic protein-2 (BMP-2), a potent osteoinductive cytokine from the transforming growth factor beta (TGF-β) family, is currently the most commonly used protein-based bone graft substitute. Although clinical use of BMP-2 has significantly increased in recent years, its prominence has also highlighted various adverse events, including induction of inflammation. This review will elucidate the relationship between BMP-2 and inflammation, with an emphasis on peripheral nerve inflammation and its sequelae. As well, we review the potential additive roles of nerve released factors with BMP2 in the context of bone formation.

AB - Bone morphogenetic protein-2 (BMP-2), a potent osteoinductive cytokine from the transforming growth factor beta (TGF-β) family, is currently the most commonly used protein-based bone graft substitute. Although clinical use of BMP-2 has significantly increased in recent years, its prominence has also highlighted various adverse events, including induction of inflammation. This review will elucidate the relationship between BMP-2 and inflammation, with an emphasis on peripheral nerve inflammation and its sequelae. As well, we review the potential additive roles of nerve released factors with BMP2 in the context of bone formation.

KW - Bone morphogenetic protein

KW - Inflammation

KW - Neural inflammation

KW - Neuritis

KW - Osteogenesis

KW - Skeletal engineering

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SN - 0972-978X

VL - 14

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JO - Journal of Orthopaedics

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BMP-2-induced bone formation and neural inflammation

Abstract

Keywords

ASJC Scopus subject areas

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