Bombesin stimulates the release of insulin and glucagon, but not pancreatic somatostatin, from the isolated perfused dog pancreas

E. Ipp, R. H. Unger

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Synthetic bombesin, perfused in the isolated canine pancreas at a rate of 340-380 ng/min for 10 min, elicited a 4-fold rise in insulin to a peak at 2 min; a rapid decline followed discontinuation of bombesin. Glucagon rose by 50% to a peak at 6 min, but remained elevated after discontinuation of the bombesin. Somato-statin-like immunoreactivity was not significantly affected by perfusion with bombesin.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalEndocrine Research
Volume6
Issue number1
DOIs
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Endocrinology

Fingerprint Dive into the research topics of 'Bombesin stimulates the release of insulin and glucagon, but not pancreatic somatostatin, from the isolated perfused dog pancreas'. Together they form a unique fingerprint.

  • Cite this