Bombesin stimulates the release of insulin and glucagon, but not pancreatic somatostatin, from the isolated perfused dog pancreas

E. Ipp, R. H. Unger

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Abstract

Synthetic bombesin, perfused in the isolated canine pancreas at a rate of 340-380 ng/min for 10 min, elicited a 4-fold rise in insulin to a peak at 2 min; a rapid decline followed discontinuation of bombesin. Glucagon rose by 50% to a peak at 6 min, but remained elevated after discontinuation of the bombesin. Somato-statin-like immunoreactivity was not significantly affected by perfusion with bombesin.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalEndocrine Research
Volume6
Issue number1
DOIs
Publication statusPublished - 1979

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ASJC Scopus subject areas

  • Endocrinology
  • Medicine(all)

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