TY - JOUR
T1 - Bone and Muscle Endocrine Functions
T2 - Unexpected Paradigms of Inter-organ Communication
AU - Karsenty, Gerard
AU - Olson, Eric N.
N1 - Funding Information:
We thank P. Ducy, M. Ferron, and S. Kousteni for critical reading of the manuscript. G.K. is a Senior Scholar in Aging from the Lawrence Ellison Foundation. Work in the G.K. lab is supported by grants from the NIA, NIDDK, and NIAMS; work in the E.N.O. lab is supported by grants from the NIH (HL-077439, HL-111665, HL-093039, DK-099653, and U01-HL-100401), Fondation Leducq Networks of Excellence, and the Robert A. Welch Foundation (grant 1-0025 to E.N.O.).
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/3/10
Y1 - 2016/3/10
N2 - Most physiological functions originate with the communication between organs. Mouse genetics has revived this holistic view of physiology through the identification of inter-organ communications that are unanticipated, functionally important, and would have been difficult to uncover otherwise. This Review highlights this point by showing how two tissues usually not seen as endocrine ones, bone and striated muscles, influence several physiological processes in a significant manner.
AB - Most physiological functions originate with the communication between organs. Mouse genetics has revived this holistic view of physiology through the identification of inter-organ communications that are unanticipated, functionally important, and would have been difficult to uncover otherwise. This Review highlights this point by showing how two tissues usually not seen as endocrine ones, bone and striated muscles, influence several physiological processes in a significant manner.
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U2 - 10.1016/j.cell.2016.02.043
DO - 10.1016/j.cell.2016.02.043
M3 - Review article
C2 - 26967290
AN - SCOPUS:84960407567
SN - 0092-8674
VL - 164
SP - 1248
EP - 1256
JO - Cell
JF - Cell
IS - 6
ER -