Bone healing in critical-size defects treated with new bioactive glass/calcium sulfate: A histologic and histometric study in rat calvaria

Maria J H Nagata, Flávia A C Furlaneto, Antonio J. Moretti, Jerry E. Bouquot, Chul W. Ahn, Michel R. Messora, Stephen E. Fucini, Valdir G. Garcia, Alvaro F. Bosco

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

This study analyzed histologically the influence of new spherical bioactive glass (NBG) particles with or without a calcium sulfate (CS) barrier on bone healing in surgically created critical-size defects (CSD) in rat calvaria. A CSD was made in each calvarium of 60 rats, which were divided into three groups: C (control): the defect was filled with blood clot only; NBG: the defect was filled with NBG only; and NBG/CS: the defect was filled with NBG covered by CS barrier. Subgroups were euthanized at 4 or 12 weeks. Amounts of new bone and remnants of implanted materials were calculated as percentages of total area of the original defect. Data were statistically analyzed. In contrast to Group C, thickness throughout defects in Groups NBG and NBG/CS was similar to the original calvarium. At 4 weeks, Group C had significantly more bone formation than Group NBG/CS. No significant differences were found between Group NBG and either Group C or Group NBG/CS. At 12 weeks, Group C had significantly more bone formation than Group NBG or NBG/CS. NBG particles, used with or without a CS barrier, maintained volume and contour of area grafted in CSD. Presence of remaining NBG particles might have accounted for smaller amount of new bone in Groups NBG and NBG/CS at 12 weeks post-operative.

Original languageEnglish (US)
Pages (from-to)269-275
Number of pages7
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume95 B
Issue number2
DOIs
StatePublished - Nov 1 2010

Keywords

  • bioactive glass 45S5
  • bone regeneration
  • bone substitutes
  • calcium sulfate

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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