Bone ingrowth into porous calcium phosphate ceramics: Influence of pulsing electromagnetic field

T. Shimizu, J. E. Zerwekh, T. Videman, K. Gill, V. Mooney, R. E. Holmes, H. K. Hagler

Research output: Contribution to journalArticle

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Abstract

The effect of a pulsing electromagnetic field (PEMF) on bone ingrowth into porous hydroxyapatite (HA) and porous tricalcium phosphate (TCP) implanted in rabbit tibiae was studied. To quantitate the biological response, a recently developed method of surface measurement using a scanning electron microscope was used. The morphometrical findings in the HA pores demonstrated a significantly greater amount of bone and thicker bone trabeculae in the PEMF group as compared with the nonpulsed control group at 3 to 4 weeks postimplantation. No significant differences for these parameters were found in the TCP pores. Histologically, more bone and wider bone trabeculae were observed in the HA implants for the PEMF-treated animals at the early time periods when compared with those of the control animals. Alternatively, the histological findings of the TCP implants were similar between these two groups. These histological results tended to correlate with the morphometrical data. Together, these results suggest that accelerated bone formation and bone maturation occurred in response to PEMF in the HA pores but was without effect in the TCP pores. This stimulatory effect is most significant after 3-4 weeks of PEMF stimulation.

Original languageEnglish (US)
Pages (from-to)248-258
Number of pages11
JournalJournal of Orthopaedic Research
Volume6
Issue number2
StatePublished - Mar 1988

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Electromagnetic Fields
Ceramics
Durapatite
Bone and Bones
Tibia
Osteogenesis
calcium phosphate
Electrons
Rabbits
Control Groups
tricalcium phosphate

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Shimizu, T., Zerwekh, J. E., Videman, T., Gill, K., Mooney, V., Holmes, R. E., & Hagler, H. K. (1988). Bone ingrowth into porous calcium phosphate ceramics: Influence of pulsing electromagnetic field. Journal of Orthopaedic Research, 6(2), 248-258.

Bone ingrowth into porous calcium phosphate ceramics : Influence of pulsing electromagnetic field. / Shimizu, T.; Zerwekh, J. E.; Videman, T.; Gill, K.; Mooney, V.; Holmes, R. E.; Hagler, H. K.

In: Journal of Orthopaedic Research, Vol. 6, No. 2, 03.1988, p. 248-258.

Research output: Contribution to journalArticle

Shimizu, T, Zerwekh, JE, Videman, T, Gill, K, Mooney, V, Holmes, RE & Hagler, HK 1988, 'Bone ingrowth into porous calcium phosphate ceramics: Influence of pulsing electromagnetic field', Journal of Orthopaedic Research, vol. 6, no. 2, pp. 248-258.
Shimizu, T. ; Zerwekh, J. E. ; Videman, T. ; Gill, K. ; Mooney, V. ; Holmes, R. E. ; Hagler, H. K. / Bone ingrowth into porous calcium phosphate ceramics : Influence of pulsing electromagnetic field. In: Journal of Orthopaedic Research. 1988 ; Vol. 6, No. 2. pp. 248-258.
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