Bone marrow and circulating stem/progenitor cells for regenerative cardiovascular therapy

Mohamad Amer Alaiti, Masakazu Ishikawa, Marco A. Costa

Research output: Contribution to journalReview article

57 Scopus citations

Abstract

Cardiovascular disease is the leading cause of death and disability in the Western world. In addition to the advancement of current therapeutic approaches to reduce the associated morbidity and mortality, regenerative medicine and cell-based therapy have been areas of continuous investigation. Circulating and bone-marrow-derived stem or endothelial progenitor cells are an attractive source for regenerative therapy in the cardiovascular field. In this review, we highlight the advantages and limitations of this approach with a focus on key observations from animal studies and clinical trials.

Original languageEnglish (US)
Pages (from-to)112-129
Number of pages18
JournalTranslational Research
Volume156
Issue number3
DOIs
StatePublished - Sep 2010
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Biochemistry, medical
  • Physiology (medical)

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