TY - JOUR
T1 - Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates
T2 - Implications for AIDS pathogenesis
AU - Paiardini, Mirko
AU - Cervasi, Barbara
AU - Engram, Jessica C.
AU - Gordon, Shari N.
AU - Klatt, Nichole R.
AU - Muthukumar, Alagarraju
AU - Else, James
AU - Mittler, Robert S.
AU - Staprans, Silvija I.
AU - Sodora, Donald L.
AU - Silvestri, Guido
PY - 2009/1/15
Y1 - 2009/1/15
N2 - Bone marrow (BM) is the key hematopoietic organ in mammals and is involved in the homeostatic proliferation of memory CD8+ T cells. Here we expanded on our previous observation that BM is a preferential site for T-cell proliferation in simian immunodeficiency virus (SIV)-infected sooty mangabeys (SMs) that do not progress to AIDS despite high viremia. We found high levels of mature T-cell proliferation, involving both naive and memory cells, in healthy SMs and rhesus macaques (RMs). In addition, we observed in both species that lineagespecific, BM-based T-cell proliferation follows antibody-mediated in vivo CD4+ or CD8+ T-cell depletion, thus indicating a role for the BM in maintaining T-cell homeostasis under depleting circumstances. We also observed that, in SIVinfected SMs, but not RMs, the level of proliferation of BM-based CD4+ T cells is higher than that of circulating CD4 + T cells. Interestingly, limited BM-based CD4+ T-cell proliferation was found in SIV-infected SMs with low CD4+ T-cell counts, suggesting a regenerative failure in these animals. Collectively, these results indicate that BM is involved in maintaining T-cell homeostasis in primates and suggest a role for BM-based CD4+ T-cell proliferation in determining the benign nature of natural SIV infection of SMs. copy; 2009 by The American Society of Hematology.
AB - Bone marrow (BM) is the key hematopoietic organ in mammals and is involved in the homeostatic proliferation of memory CD8+ T cells. Here we expanded on our previous observation that BM is a preferential site for T-cell proliferation in simian immunodeficiency virus (SIV)-infected sooty mangabeys (SMs) that do not progress to AIDS despite high viremia. We found high levels of mature T-cell proliferation, involving both naive and memory cells, in healthy SMs and rhesus macaques (RMs). In addition, we observed in both species that lineagespecific, BM-based T-cell proliferation follows antibody-mediated in vivo CD4+ or CD8+ T-cell depletion, thus indicating a role for the BM in maintaining T-cell homeostasis under depleting circumstances. We also observed that, in SIVinfected SMs, but not RMs, the level of proliferation of BM-based CD4+ T cells is higher than that of circulating CD4 + T cells. Interestingly, limited BM-based CD4+ T-cell proliferation was found in SIV-infected SMs with low CD4+ T-cell counts, suggesting a regenerative failure in these animals. Collectively, these results indicate that BM is involved in maintaining T-cell homeostasis in primates and suggest a role for BM-based CD4+ T-cell proliferation in determining the benign nature of natural SIV infection of SMs. copy; 2009 by The American Society of Hematology.
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U2 - 10.1182/blood-2008-06-159442
DO - 10.1182/blood-2008-06-159442
M3 - Article
C2 - 18832134
AN - SCOPUS:60249093936
SN - 0006-4971
VL - 113
SP - 612
EP - 621
JO - Blood
JF - Blood
IS - 3
ER -