Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates

Implications for AIDS pathogenesis

Mirko Paiardini, Barbara Cervasi, Jessica C. Engram, Shari N. Gordon, Nichole R. Klatt, Alagarraju Muthukumar, James Else, Robert S. Mittler, Silvija I. Staprans, Donald L. Sodora, Guido Silvestri

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Bone marrow (BM) is the key hematopoietic organ in mammals and is involved in the homeostatic proliferation of memory CD8 + T cells. Here we expanded on our previous observation that BM is a preferential site for T-cell proliferation in simian immunodeficiency virus (SIV)-infected sooty mangabeys (SMs) that do not progress to AIDS despite high viremia. We found high levels of mature T-cell proliferation, involving both naive and memory cells, in healthy SMs and rhesus macaques (RMs). In addition, we observed in both species that lineagespecific, BM-based T-cell proliferation follows antibody-mediated in vivo CD4 + or CD8 + T-cell depletion, thus indicating a role for the BM in maintaining T-cell homeostasis under depleting circumstances. We also observed that, in SIVinfected SMs, but not RMs, the level of proliferation of BM-based CD4 + T cells is higher than that of circulating CD4 + T cells. Interestingly, limited BM-based CD4 + T-cell proliferation was found in SIV-infected SMs with low CD4+ T-cell counts, suggesting a regenerative failure in these animals. Collectively, these results indicate that BM is involved in maintaining T-cell homeostasis in primates and suggest a role for BM-based CD4 + T-cell proliferation in determining the benign nature of natural SIV infection of SMs. copy; 2009 by The American Society of Hematology.

Original languageEnglish (US)
Pages (from-to)612-621
Number of pages10
JournalBlood
Volume113
Issue number3
DOIs
StatePublished - Jan 15 2009

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T-cells
Primates
Bone
Acquired Immunodeficiency Syndrome
Bone Marrow
Cercocebus atys
T-Lymphocytes
Cell proliferation
Simian Immunodeficiency Virus
Cell Proliferation
Viruses
Macaca mulatta
Homeostasis
Data storage equipment
Mammals
Viremia
Virus Diseases
CD4 Lymphocyte Count
Animals

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates : Implications for AIDS pathogenesis. / Paiardini, Mirko; Cervasi, Barbara; Engram, Jessica C.; Gordon, Shari N.; Klatt, Nichole R.; Muthukumar, Alagarraju; Else, James; Mittler, Robert S.; Staprans, Silvija I.; Sodora, Donald L.; Silvestri, Guido.

In: Blood, Vol. 113, No. 3, 15.01.2009, p. 612-621.

Research output: Contribution to journalArticle

Paiardini, M, Cervasi, B, Engram, JC, Gordon, SN, Klatt, NR, Muthukumar, A, Else, J, Mittler, RS, Staprans, SI, Sodora, DL & Silvestri, G 2009, 'Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates: Implications for AIDS pathogenesis', Blood, vol. 113, no. 3, pp. 612-621. https://doi.org/10.1182/blood-2008-06-159442
Paiardini, Mirko ; Cervasi, Barbara ; Engram, Jessica C. ; Gordon, Shari N. ; Klatt, Nichole R. ; Muthukumar, Alagarraju ; Else, James ; Mittler, Robert S. ; Staprans, Silvija I. ; Sodora, Donald L. ; Silvestri, Guido. / Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates : Implications for AIDS pathogenesis. In: Blood. 2009 ; Vol. 113, No. 3. pp. 612-621.
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