Bone Morphogenetic Protein Usage in Anterior Lumbar Interbody Fusion: What Else Can Go Wrong?

Elias Elias, Zeina Nasser, Lona Winegan, Terence Verla, Ibrahim Omeis

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background Bone morphogenetic protein (BMP) graft showed promising outcome during early phases of its use. However, unreported adverse events and off-label use shattered its safe profile and raised concerns regarding its indication. In 2008 the U.S. Food and Drug Administration prohibited its use in anterior cervical spine procedures due to the possibility of edema, hematoma, and need to intubate. At the molecular level, BMPs act as multifactorial growth factors playing a role in cartilage, heart, and bone formation. However, its unfavorable effect on bone overgrowth or heterotopic ossification post spine surgeries has been described. Reported cases in the literature were limited to epidural bone formation. Case Description We present a rare and interesting case of a 59-year-old female, in whom BMP caused intradural bone growth several years after an anterior lumbar interbody fusion surgery. Conclusion Caution must be exercised while using BMPs because of inadvertent complications.

Original languageEnglish (US)
Pages (from-to)55-59
Number of pages5
JournalWorld neurosurgery
StatePublished - Mar 2018
Externally publishedYes


  • Bone morphogenetic proteins
  • Fusion
  • Intradural bone growth
  • Lumbar spine
  • Safety

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


Dive into the research topics of 'Bone Morphogenetic Protein Usage in Anterior Lumbar Interbody Fusion: What Else Can Go Wrong?'. Together they form a unique fingerprint.

Cite this