Botulinum Toxin Treatment in Depression

M. Axel Wollmer, Michelle Magid, Tillmann H C Kruger

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Botulinum toxin injection is a new and evolving approach in the treatment of depression. Paralyzing muscles in the glabellar (forehead) region, which are responsible for facial expression of negative emotions, may improve symptoms of depression. A series of studies have consistently demonstrated that a single treatment of botulinum toxin in the forehead region can cause a strong and sustained improvement in mood in patients with depression. Mood lifting effects may contribute to the popularity of botulinum toxin treatment in esthetic medicine. Future clinical research may reveal if botulinum toxin can also be used to counteract the experience of negative emotions in other psychiatric disorders besides depression.

Original languageEnglish (US)
Title of host publicationPractical Psychodermatology
PublisherWiley Blackwell
Number of pages4
ISBN (Print)9781118560648, 9781118560686
Publication statusPublished - May 5 2014



  • Botulinum toxin
  • Depression
  • Facial feedback
  • Facial muscles

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wollmer, M. A., Magid, M., & Kruger, T. H. C. (2014). Botulinum Toxin Treatment in Depression. In Practical Psychodermatology (Vol. 9781118560686, pp. 216-219). Wiley Blackwell.