BP and renal outcomes in diabetic kidney disease

The veterans affairs nephropathy in diabetes trial

VA NEPHRON-D Study Group

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background and objectives Proteinuric diabetic kidney disease frequently progresses to ESRD. Control of BP delays progression, but the optimal BP to improve outcomes remains unclear. The objective of this analysiswas to evaluate the relationship between BP and renal outcomes in proteinuric diabetic kidney disease. Design, setting, participants, & measurements BP data from all 1448 randomized participants in the Veterans AffairsNephropathy inDiabetes Trialwere included in a post hoc analysis. The associations of mean on–treatment BPwith the primary end point (decline in eGFR, ESRD, or death), renal end point (decline in eGFR or ESRD), rate of eGFR decline, and mortality were measured. Results The median (25th, 75th percentile) follow-up time was 2.2 (1.2, 3.0) years. There were 284 primary end points. In univariate analyses, both mean systolic and mean diastolic BPs were strongly associated (P

Original languageEnglish (US)
Pages (from-to)2159-2169
Number of pages11
JournalClinical Journal of the American Society of Nephrology
Volume10
Issue number12
DOIs
StatePublished - Dec 7 2015

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Diabetic Nephropathies
Veterans
Chronic Kidney Failure
Kidney
Mortality

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine

Cite this

BP and renal outcomes in diabetic kidney disease : The veterans affairs nephropathy in diabetes trial. / VA NEPHRON-D Study Group.

In: Clinical Journal of the American Society of Nephrology, Vol. 10, No. 12, 07.12.2015, p. 2159-2169.

Research output: Contribution to journalArticle

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abstract = "Background and objectives Proteinuric diabetic kidney disease frequently progresses to ESRD. Control of BP delays progression, but the optimal BP to improve outcomes remains unclear. The objective of this analysiswas to evaluate the relationship between BP and renal outcomes in proteinuric diabetic kidney disease. Design, setting, participants, & measurements BP data from all 1448 randomized participants in the Veterans AffairsNephropathy inDiabetes Trialwere included in a post hoc analysis. The associations of mean on–treatment BPwith the primary end point (decline in eGFR, ESRD, or death), renal end point (decline in eGFR or ESRD), rate of eGFR decline, and mortality were measured. Results The median (25th, 75th percentile) follow-up time was 2.2 (1.2, 3.0) years. There were 284 primary end points. In univariate analyses, both mean systolic and mean diastolic BPs were strongly associated (P",
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AU - Zhang, Jane H.

AU - Emanuele, Nicholas V.

AU - Whaley-Connell, Adam

AU - Palevsky, Paul M.

AU - Reilly, Robert F.

AU - Guarino, Peter

AU - Fried, Linda F.

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AB - Background and objectives Proteinuric diabetic kidney disease frequently progresses to ESRD. Control of BP delays progression, but the optimal BP to improve outcomes remains unclear. The objective of this analysiswas to evaluate the relationship between BP and renal outcomes in proteinuric diabetic kidney disease. Design, setting, participants, & measurements BP data from all 1448 randomized participants in the Veterans AffairsNephropathy inDiabetes Trialwere included in a post hoc analysis. The associations of mean on–treatment BPwith the primary end point (decline in eGFR, ESRD, or death), renal end point (decline in eGFR or ESRD), rate of eGFR decline, and mortality were measured. Results The median (25th, 75th percentile) follow-up time was 2.2 (1.2, 3.0) years. There were 284 primary end points. In univariate analyses, both mean systolic and mean diastolic BPs were strongly associated (P

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