TY - JOUR
T1 - Brain γ-Aminobutyric Acid Abnormality in Tardive Dyskinesia
T2 - Reduction in Cerebrospinal Fluid GABA Levels and Therapeutic Response to GABA Agonist Treatment
AU - Thaker, G. K.
AU - Tamminga, C. A.
AU - Alphs, L. D.
AU - Lafferman, J.
AU - Ferraro, T. N.
AU - Hare, T. A.
PY - 1987/6
Y1 - 1987/6
N2 - A double-blind, placebo-controlled trial of γ-vinyl γ-aminobutyric acid (GVG) and 4,5,6,7-tetrahydroisoxazolo-(5,4-c) pyridine-3-ol (THIP) was carried out in drug-free schizophrenic patients with tardive dyskinesia. A significant decrease in dyskinetic symptoms occurred with the administration of GVG, associated with a twofold increase in cerebrospinal fluid levels of GABA; THIP produced a more moderate, yet consistent decrease in the involuntary movements. A pathophysiologic role for γ-aminobutyric acid (GABA)-mediated neuronal transmission in tardive dyskinesia was explored by analyzing cerebrospinal fluid GABA concentrations in drugfree schizophrenic patients with and without tardive dyskinesia. A significant reduction in cerebrospinal fluid levels of GABA was observed in the dyskinetic schizophrenics compared with the nondyskinetic controls. These data compliment a growing body of experimental evidence suggesting a critical role for GABA-ergic neurons in the pathophysiology of tardive dyskinesia.
AB - A double-blind, placebo-controlled trial of γ-vinyl γ-aminobutyric acid (GVG) and 4,5,6,7-tetrahydroisoxazolo-(5,4-c) pyridine-3-ol (THIP) was carried out in drug-free schizophrenic patients with tardive dyskinesia. A significant decrease in dyskinetic symptoms occurred with the administration of GVG, associated with a twofold increase in cerebrospinal fluid levels of GABA; THIP produced a more moderate, yet consistent decrease in the involuntary movements. A pathophysiologic role for γ-aminobutyric acid (GABA)-mediated neuronal transmission in tardive dyskinesia was explored by analyzing cerebrospinal fluid GABA concentrations in drugfree schizophrenic patients with and without tardive dyskinesia. A significant reduction in cerebrospinal fluid levels of GABA was observed in the dyskinetic schizophrenics compared with the nondyskinetic controls. These data compliment a growing body of experimental evidence suggesting a critical role for GABA-ergic neurons in the pathophysiology of tardive dyskinesia.
UR - http://www.scopus.com/inward/record.url?scp=0023276203&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023276203&partnerID=8YFLogxK
U2 - 10.1001/archpsyc.1987.01800180032006
DO - 10.1001/archpsyc.1987.01800180032006
M3 - Article
C2 - 3034188
AN - SCOPUS:0023276203
SN - 0003-990X
VL - 44
SP - 522
EP - 529
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 6
ER -