Brain activation during a social attribution task in adolescents with moderate to severe traumatic brain injury

Randall S. Scheibel, Mary R. Newsome, Elisabeth A. Wilde, Michelle M. McClelland, Gerri Hanten, Daniel C. Krawczyk, Lori G. Cook, Zili D. Chu, Ana C. Vásquez, Ragini Yallampalli, Xiaodi Lin, Jill V. Hunter, Harvey S. Levin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The ability to make accurate judgments about the mental states of others, sometimes referred to as theory of mind (ToM), is often impaired following traumatic brain injury (TBI), and this deficit may contribute to problems with interpersonal relationships. The present study used an animated social attribution task (SAT) with functional magnetic resonance imaging (fMRI) to examine structures mediating ToM in adolescents with moderate to severe TBI. The study design also included a comparison group of matched, typically developing (TD) adolescents. The TD group exhibited activation within a number of areas that are thought to be relevant to ToM, including the medial prefrontal and anterior cingulate cortex, fusiform gyrus, and posterior temporal and parietal areas. The TBI subjects had significant activation within many of these same areas, but their activation was generally more intense and excluded the medial prefrontal cortex. Exploratory regression analyses indicated a negative relation between ToM-related activation and measures of white matter integrity derived from diffusion tensor imaging, while there was also a positive relation between activation and lesion volume. These findings are consistent with alterations in the level and pattern of brain activation that may be due to the combined influence of diffuse axonal injury and focal lesions.

Original languageEnglish (US)
Pages (from-to)582-598
Number of pages17
JournalSocial Neuroscience
Volume6
Issue number5-6
DOIs
StatePublished - Oct 2011

Fingerprint

Theory of Mind
activation
attribution
brain
adolescent
Brain
lesion
Diffuse Axonal Injury
Diffusion Tensor Imaging
Aptitude
Gyrus Cinguli
Temporal Lobe
Prefrontal Cortex
Research Design
Regression Analysis
Magnetic Resonance Imaging
integrity
Traumatic Brain Injury
deficit
Group

Keywords

  • Adolescents
  • Diffusion tensor imaging
  • fMRI
  • Social cognition
  • Traumatic brain injury

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Development
  • Social Psychology

Cite this

Brain activation during a social attribution task in adolescents with moderate to severe traumatic brain injury. / Scheibel, Randall S.; Newsome, Mary R.; Wilde, Elisabeth A.; McClelland, Michelle M.; Hanten, Gerri; Krawczyk, Daniel C.; Cook, Lori G.; Chu, Zili D.; Vásquez, Ana C.; Yallampalli, Ragini; Lin, Xiaodi; Hunter, Jill V.; Levin, Harvey S.

In: Social Neuroscience, Vol. 6, No. 5-6, 10.2011, p. 582-598.

Research output: Contribution to journalArticle

Scheibel, RS, Newsome, MR, Wilde, EA, McClelland, MM, Hanten, G, Krawczyk, DC, Cook, LG, Chu, ZD, Vásquez, AC, Yallampalli, R, Lin, X, Hunter, JV & Levin, HS 2011, 'Brain activation during a social attribution task in adolescents with moderate to severe traumatic brain injury', Social Neuroscience, vol. 6, no. 5-6, pp. 582-598. https://doi.org/10.1080/17470919.2011.588844
Scheibel, Randall S. ; Newsome, Mary R. ; Wilde, Elisabeth A. ; McClelland, Michelle M. ; Hanten, Gerri ; Krawczyk, Daniel C. ; Cook, Lori G. ; Chu, Zili D. ; Vásquez, Ana C. ; Yallampalli, Ragini ; Lin, Xiaodi ; Hunter, Jill V. ; Levin, Harvey S. / Brain activation during a social attribution task in adolescents with moderate to severe traumatic brain injury. In: Social Neuroscience. 2011 ; Vol. 6, No. 5-6. pp. 582-598.
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