Brain and bone aluminum: A comparison of aluminum intake in rats

Michael J. Nicar, Donald D. McIntire, Laura K. Pak

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Serum and bone aluminum concentrations were significantly higher in young rats fed pharmacological doses of aluminum for 29 d than in control rats that did not receive extra aluminum. The control rats had a serum aluminum level of 18 ± 3 (SE) ppb and a bone aluminum level of 19.1 ± 1.0 ppm; the aluminum‐exposed rats had a serum aluminum level of 44 ± 7 ppm and a bone aluminum level of 27.2 ± 2.4 ppm. Rats fed a diet analogous to aluminum‐contaminated foods had control levels of serum and bone aluminum. Increases of approximately 1 ppm (over the control level) in brain aluminum concentrations of both dosed groups of rats were not statistically significant. The aluminum intake correlated with serum and bone aluminum concentrations, and the serum aluminum concentrations correlated with the bone aluminum concentrations. However, the concentrations of brain aluminum did not correlate with either aluminum intake or serum aluminum levels.

Original languageEnglish (US)
Pages (from-to)1331-1336
Number of pages6
JournalEnvironmental Toxicology and Chemistry
Issue number9
StatePublished - Sep 1992



  • Aluminum ingestion
  • Bone
  • Brain
  • Rats
  • Serum

ASJC Scopus subject areas

  • Environmental Chemistry
  • Health, Toxicology and Mutagenesis

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