Brain calcification in hypoxic-ischemic lesions: An autopsy review

Mohammed Q. Ansari, Carol A. Chincanchan, Dawna L. Armstrong

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Calcification of ischemic lesions in a child's brain is well recognized by pathologists; however, clinicians and radiologists usually associate cerebral calcification with infections, particularly the TORCH organisms. We illustrate this phenomenon in a 5-month-old infant with extensive, calcified, multicystic encephalomalacia without evidence of a cerebral infection. In order to ascertain the incidence of cerebral calcification in pure hypoxic-ischemic lesions, we retrospectively analyzed 486 consecutive autopsies. Ninety-nine patients had histologic evidence of cerebral hypoxic-ischemic lesions and hypoxia or ischemia. Thirty-nine of these patients displayed microscopic calcification; 23 patients had slight, 12 had minor, and 4 had prominent calcifications. Prominent calcification lesions were large enough to be detected by routine radiologic methods. Correlations between degree of calcification and the underlying disease process and between the gestational age and the length of survival were not statistically significant. This study illustrates the very frequent occurrence of brain calcification in ischemic brain lesions in children. It is necessary to include this diagnosis in the differential diagnosis of cerebral calcification.

Original languageEnglish (US)
Pages (from-to)94-101
Number of pages8
JournalPediatric Neurology
Volume6
Issue number2
DOIs
StatePublished - 1990

Fingerprint

Autopsy
Brain
Encephalomalacia
Infection
Gestational Age
Differential Diagnosis
Ischemia
Survival
Incidence
Radiologists
Hypoxia
Pathologists

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Brain calcification in hypoxic-ischemic lesions : An autopsy review. / Ansari, Mohammed Q.; Chincanchan, Carol A.; Armstrong, Dawna L.

In: Pediatric Neurology, Vol. 6, No. 2, 1990, p. 94-101.

Research output: Contribution to journalArticle

Ansari, Mohammed Q. ; Chincanchan, Carol A. ; Armstrong, Dawna L. / Brain calcification in hypoxic-ischemic lesions : An autopsy review. In: Pediatric Neurology. 1990 ; Vol. 6, No. 2. pp. 94-101.
@article{56df32562f2c4b269f7692f42fa8080f,
title = "Brain calcification in hypoxic-ischemic lesions: An autopsy review",
abstract = "Calcification of ischemic lesions in a child's brain is well recognized by pathologists; however, clinicians and radiologists usually associate cerebral calcification with infections, particularly the TORCH organisms. We illustrate this phenomenon in a 5-month-old infant with extensive, calcified, multicystic encephalomalacia without evidence of a cerebral infection. In order to ascertain the incidence of cerebral calcification in pure hypoxic-ischemic lesions, we retrospectively analyzed 486 consecutive autopsies. Ninety-nine patients had histologic evidence of cerebral hypoxic-ischemic lesions and hypoxia or ischemia. Thirty-nine of these patients displayed microscopic calcification; 23 patients had slight, 12 had minor, and 4 had prominent calcifications. Prominent calcification lesions were large enough to be detected by routine radiologic methods. Correlations between degree of calcification and the underlying disease process and between the gestational age and the length of survival were not statistically significant. This study illustrates the very frequent occurrence of brain calcification in ischemic brain lesions in children. It is necessary to include this diagnosis in the differential diagnosis of cerebral calcification.",
author = "Ansari, {Mohammed Q.} and Chincanchan, {Carol A.} and Armstrong, {Dawna L.}",
year = "1990",
doi = "10.1016/0887-8994(90)90041-X",
language = "English (US)",
volume = "6",
pages = "94--101",
journal = "Pediatric Neurology",
issn = "0887-8994",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Brain calcification in hypoxic-ischemic lesions

T2 - An autopsy review

AU - Ansari, Mohammed Q.

AU - Chincanchan, Carol A.

AU - Armstrong, Dawna L.

PY - 1990

Y1 - 1990

N2 - Calcification of ischemic lesions in a child's brain is well recognized by pathologists; however, clinicians and radiologists usually associate cerebral calcification with infections, particularly the TORCH organisms. We illustrate this phenomenon in a 5-month-old infant with extensive, calcified, multicystic encephalomalacia without evidence of a cerebral infection. In order to ascertain the incidence of cerebral calcification in pure hypoxic-ischemic lesions, we retrospectively analyzed 486 consecutive autopsies. Ninety-nine patients had histologic evidence of cerebral hypoxic-ischemic lesions and hypoxia or ischemia. Thirty-nine of these patients displayed microscopic calcification; 23 patients had slight, 12 had minor, and 4 had prominent calcifications. Prominent calcification lesions were large enough to be detected by routine radiologic methods. Correlations between degree of calcification and the underlying disease process and between the gestational age and the length of survival were not statistically significant. This study illustrates the very frequent occurrence of brain calcification in ischemic brain lesions in children. It is necessary to include this diagnosis in the differential diagnosis of cerebral calcification.

AB - Calcification of ischemic lesions in a child's brain is well recognized by pathologists; however, clinicians and radiologists usually associate cerebral calcification with infections, particularly the TORCH organisms. We illustrate this phenomenon in a 5-month-old infant with extensive, calcified, multicystic encephalomalacia without evidence of a cerebral infection. In order to ascertain the incidence of cerebral calcification in pure hypoxic-ischemic lesions, we retrospectively analyzed 486 consecutive autopsies. Ninety-nine patients had histologic evidence of cerebral hypoxic-ischemic lesions and hypoxia or ischemia. Thirty-nine of these patients displayed microscopic calcification; 23 patients had slight, 12 had minor, and 4 had prominent calcifications. Prominent calcification lesions were large enough to be detected by routine radiologic methods. Correlations between degree of calcification and the underlying disease process and between the gestational age and the length of survival were not statistically significant. This study illustrates the very frequent occurrence of brain calcification in ischemic brain lesions in children. It is necessary to include this diagnosis in the differential diagnosis of cerebral calcification.

UR - http://www.scopus.com/inward/record.url?scp=0025170719&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025170719&partnerID=8YFLogxK

U2 - 10.1016/0887-8994(90)90041-X

DO - 10.1016/0887-8994(90)90041-X

M3 - Article

C2 - 2340036

AN - SCOPUS:0025170719

VL - 6

SP - 94

EP - 101

JO - Pediatric Neurology

JF - Pediatric Neurology

SN - 0887-8994

IS - 2

ER -