Brain choline acetyltransferase activity and neuropeptide Y concentrations in Alzheimer's disease

Norman L. Foster, Carol A. Tamminga, Thomas L. O'Donohue, Kenji Tanimoto, Edward D. Bird, Thomas N. Chase

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Choline acetyltransferase (ChAT) activity and neuropeptide Y (NPY) levels in post-mortem tissues from patients with histologically proven Alzheimer's disease were compared with age-matched neurologically normal control individuals. Despite the high NPY concentrations in human cerebral cortex, no significant abnormalities were found. However, ChAT activity was reduced throughout the cortex, without a relationship to areas of functional deficit, as previously identified using fluorodeoxyglucose. These results lend further support to the concept of Alzheimer's disease as a highly selective neurodegenerative disorder.

Original languageEnglish (US)
Pages (from-to)71-75
Number of pages5
JournalNeuroscience Letters
Volume63
Issue number1
DOIs
StatePublished - Jan 2 1986

Fingerprint

Choline O-Acetyltransferase
Neuropeptide Y
Alzheimer Disease
Brain
Neurodegenerative Diseases
Cerebral Cortex

Keywords

  • Alzheimer's disease
  • cerebral cortex
  • choline acetyltransferase
  • cholinergic
  • dementia
  • neuropeptide
  • neuropeptide Y

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Brain choline acetyltransferase activity and neuropeptide Y concentrations in Alzheimer's disease. / Foster, Norman L.; Tamminga, Carol A.; O'Donohue, Thomas L.; Tanimoto, Kenji; Bird, Edward D.; Chase, Thomas N.

In: Neuroscience Letters, Vol. 63, No. 1, 02.01.1986, p. 71-75.

Research output: Contribution to journalArticle

Foster, Norman L. ; Tamminga, Carol A. ; O'Donohue, Thomas L. ; Tanimoto, Kenji ; Bird, Edward D. ; Chase, Thomas N. / Brain choline acetyltransferase activity and neuropeptide Y concentrations in Alzheimer's disease. In: Neuroscience Letters. 1986 ; Vol. 63, No. 1. pp. 71-75.
@article{158de08231694f569ca74401aaceb8e0,
title = "Brain choline acetyltransferase activity and neuropeptide Y concentrations in Alzheimer's disease",
abstract = "Choline acetyltransferase (ChAT) activity and neuropeptide Y (NPY) levels in post-mortem tissues from patients with histologically proven Alzheimer's disease were compared with age-matched neurologically normal control individuals. Despite the high NPY concentrations in human cerebral cortex, no significant abnormalities were found. However, ChAT activity was reduced throughout the cortex, without a relationship to areas of functional deficit, as previously identified using fluorodeoxyglucose. These results lend further support to the concept of Alzheimer's disease as a highly selective neurodegenerative disorder.",
keywords = "Alzheimer's disease, cerebral cortex, choline acetyltransferase, cholinergic, dementia, neuropeptide, neuropeptide Y",
author = "Foster, {Norman L.} and Tamminga, {Carol A.} and O'Donohue, {Thomas L.} and Kenji Tanimoto and Bird, {Edward D.} and Chase, {Thomas N.}",
year = "1986",
month = "1",
day = "2",
doi = "10.1016/0304-3940(86)90015-7",
language = "English (US)",
volume = "63",
pages = "71--75",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Brain choline acetyltransferase activity and neuropeptide Y concentrations in Alzheimer's disease

AU - Foster, Norman L.

AU - Tamminga, Carol A.

AU - O'Donohue, Thomas L.

AU - Tanimoto, Kenji

AU - Bird, Edward D.

AU - Chase, Thomas N.

PY - 1986/1/2

Y1 - 1986/1/2

N2 - Choline acetyltransferase (ChAT) activity and neuropeptide Y (NPY) levels in post-mortem tissues from patients with histologically proven Alzheimer's disease were compared with age-matched neurologically normal control individuals. Despite the high NPY concentrations in human cerebral cortex, no significant abnormalities were found. However, ChAT activity was reduced throughout the cortex, without a relationship to areas of functional deficit, as previously identified using fluorodeoxyglucose. These results lend further support to the concept of Alzheimer's disease as a highly selective neurodegenerative disorder.

AB - Choline acetyltransferase (ChAT) activity and neuropeptide Y (NPY) levels in post-mortem tissues from patients with histologically proven Alzheimer's disease were compared with age-matched neurologically normal control individuals. Despite the high NPY concentrations in human cerebral cortex, no significant abnormalities were found. However, ChAT activity was reduced throughout the cortex, without a relationship to areas of functional deficit, as previously identified using fluorodeoxyglucose. These results lend further support to the concept of Alzheimer's disease as a highly selective neurodegenerative disorder.

KW - Alzheimer's disease

KW - cerebral cortex

KW - choline acetyltransferase

KW - cholinergic

KW - dementia

KW - neuropeptide

KW - neuropeptide Y

UR - http://www.scopus.com/inward/record.url?scp=0022623662&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022623662&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(86)90015-7

DO - 10.1016/0304-3940(86)90015-7

M3 - Article

C2 - 3754039

AN - SCOPUS:0022623662

VL - 63

SP - 71

EP - 75

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -