Brain choline acetyltransferase activity and neuropeptide Y concentrations in Alzheimer's disease

Norman L. Foster, Carol A. Tamminga, Thomas L. O'Donohue, Kenji Tanimoto, Edward D. Bird, Thomas N. Chase

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Choline acetyltransferase (ChAT) activity and neuropeptide Y (NPY) levels in post-mortem tissues from patients with histologically proven Alzheimer's disease were compared with age-matched neurologically normal control individuals. Despite the high NPY concentrations in human cerebral cortex, no significant abnormalities were found. However, ChAT activity was reduced throughout the cortex, without a relationship to areas of functional deficit, as previously identified using fluorodeoxyglucose. These results lend further support to the concept of Alzheimer's disease as a highly selective neurodegenerative disorder.

Original languageEnglish (US)
Pages (from-to)71-75
Number of pages5
JournalNeuroscience Letters
Volume63
Issue number1
DOIs
StatePublished - Jan 2 1986

Keywords

  • Alzheimer's disease
  • cerebral cortex
  • choline acetyltransferase
  • cholinergic
  • dementia
  • neuropeptide
  • neuropeptide Y

ASJC Scopus subject areas

  • Neuroscience(all)

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