Abstract
Choline acetyltransferase (ChAT) activity and neuropeptide Y (NPY) levels in post-mortem tissues from patients with histologically proven Alzheimer's disease were compared with age-matched neurologically normal control individuals. Despite the high NPY concentrations in human cerebral cortex, no significant abnormalities were found. However, ChAT activity was reduced throughout the cortex, without a relationship to areas of functional deficit, as previously identified using fluorodeoxyglucose. These results lend further support to the concept of Alzheimer's disease as a highly selective neurodegenerative disorder.
Original language | English (US) |
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Pages (from-to) | 71-75 |
Number of pages | 5 |
Journal | Neuroscience letters |
Volume | 63 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2 1986 |
Keywords
- Alzheimer's disease
- cerebral cortex
- choline acetyltransferase
- cholinergic
- dementia
- neuropeptide
- neuropeptide Y
ASJC Scopus subject areas
- General Neuroscience