Brain-derived neurotrophic factor alters the synaptic modification threshold in visual cortex

Kimberly M. Huber, Nathaniel B. Sawtell, Mark F. Bear

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

The effects of brain-derived neurotrophic factor (BDNF) were investigated on synaptic transmission and two forms of activity-dependent synaptic plasticity, long-term potentiation (LTP) and long-term depression (LTD), in visual cortex slices prepared from young (P21-28) rats. The slices treated for 2-5 h in BDNF showed no difference from control slices when a 'strong' tetanus was used (theta-burst stimulation) to elicit a maximal level of LTP but displayed significantly greater synaptic potentiation in response to a 'weak' (20 Hz) tetanus. The BDNF-treated slices also showed significantly less LTD in response to a 1 Hz tetanus. Thus, BDNF treatment alters the relationship between stimulation frequency and synaptic plasticity in the visual cortex, shifting the modification threshold to the left. The effects of BDNF on LTP and LTD induction may be attributed to the significant enhancement of synaptic responses that was observed during conditioning stimulation. These data suggest that one role of BDNF during development of the visual cortex may be to modulate the properties of synaptic plasticity, enhancing synaptic strengthening and reducing synaptic weakening processes which contribute to the formation of specific synaptic connections.

Original languageEnglish (US)
Pages (from-to)571-579
Number of pages9
JournalNeuropharmacology
Volume37
Issue number4-5
DOIs
StatePublished - Apr 5 1998

Fingerprint

Brain-Derived Neurotrophic Factor
Visual Cortex
Neuronal Plasticity
Long-Term Potentiation
Tetanus
Synaptic Transmission

Keywords

  • Long-term depression
  • Long-term potentiation
  • Neurotrophin
  • Visual cortical plasticity

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

Brain-derived neurotrophic factor alters the synaptic modification threshold in visual cortex. / Huber, Kimberly M.; Sawtell, Nathaniel B.; Bear, Mark F.

In: Neuropharmacology, Vol. 37, No. 4-5, 05.04.1998, p. 571-579.

Research output: Contribution to journalArticle

Huber, Kimberly M. ; Sawtell, Nathaniel B. ; Bear, Mark F. / Brain-derived neurotrophic factor alters the synaptic modification threshold in visual cortex. In: Neuropharmacology. 1998 ; Vol. 37, No. 4-5. pp. 571-579.
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