Brain-derived neurotrophic factor and neuropsychiatric disorders

Anita E. Autry, Lisa M Monteggia

Research output: Contribution to journalArticle

586 Citations (Scopus)

Abstract

Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central nervous system (CNS). It is essential for the development of the CNS and for neuronal plasticity. Because BDNF plays a crucial role in development and plasticity of the brain, it is widely implicated in psychiatric diseases. This review provides a summary of clinical and preclinical evidence for the involvement of this ubiquitous growth factor in major depressive disorder, schizophrenia, addiction, Rett syndrome, as well as other psychiatric and neurodevelopmental diseases. In addition, the review includes a discussion of the role of BDNF in the mechanism of action of pharmacological therapies currently used to treat these diseases, such antidepressants and antipsychotics. The review also covers a critique of experimental therapies such as BDNF mimetics and discusses the value of BDNF as a target for future drug development.

Original languageEnglish (US)
Pages (from-to)238-258
Number of pages21
JournalPharmacological Reviews
Volume64
Issue number2
DOIs
StatePublished - Apr 2012

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Brain-Derived Neurotrophic Factor
Psychiatry
Intercellular Signaling Peptides and Proteins
Molecular Mechanisms of Pharmacological Action
Central Nervous System
Rett Syndrome
Investigational Therapies
Neuronal Plasticity
Major Depressive Disorder
Antidepressive Agents
Antipsychotic Agents
Schizophrenia
Brain
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Brain-derived neurotrophic factor and neuropsychiatric disorders. / Autry, Anita E.; Monteggia, Lisa M.

In: Pharmacological Reviews, Vol. 64, No. 2, 04.2012, p. 238-258.

Research output: Contribution to journalArticle

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