Brain dynamical disentrainment by anti-epileptic drugs in rat and human status epilepticus

L. B. Good, S. Sabesan, L. D. Iasemidis, K. Tsakalis, D. M. Treiman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Abstract

In this paper, we utilize a measure of brain dynamics, namely the short-term largest Lyapunov exponent (STL max), to evaluate the efficacy of treatment in epileptic animals and humans with known antiepileptic drugs (AED) like diazepam and phenobarbital during status epilepticus (SE). This measure is estimated from analysis of electroencephalographic (EEG) recordings at multiple brain locations in both a SE patient and a cobalt/homocysteine thiolactone SE-induced animal. Techniques from optimization theory and statistics are applied to select optimal sets of brain sites, whose dynamics are then measured over time to study their entrainment/disentrainment. Results from such analysis indicate that the observed abnormal spatio-temporal dynamical entrainment in SE is reversed by AED administration (resetting of brain dynamics). These results may provide a potential use of nonlinear dynamical measures in the evaluation of the efficacy of AEDs and the development of new treatment strategies in epilepsy.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages176-179
Number of pages4
Volume26 I
StatePublished - 2004
EventConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States
Duration: Sep 1 2004Sep 5 2004

Other

OtherConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004
CountryUnited States
CitySan Francisco, CA
Period9/1/049/5/04

Keywords

  • Antiepileptic drugs
  • Brain dynamics
  • Brain resetting
  • EEG
  • Epilepsy
  • Nonlinear analysis
  • Status epilepticus

ASJC Scopus subject areas

  • Bioengineering

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  • Cite this

    Good, L. B., Sabesan, S., Iasemidis, L. D., Tsakalis, K., & Treiman, D. M. (2004). Brain dynamical disentrainment by anti-epileptic drugs in rat and human status epilepticus. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 26 I, pp. 176-179)