Brain gray matter phenotypes across the psychosis dimension

Elena I. Ivleva, Anup S. Bidesi, Binu P. Thomas, Shashwath A. Meda, Alan Francis, Amanda F. Moates, Bradley Witte, Matcheri S. Keshavan, Carol A. Tamminga

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

This study sought to examine whole brain and regional gray matter (GM) phenotypes across the schizophrenia (SZ)-bipolar disorder psychosis dimension using voxel-based morphometry (VBM 8.0 with DARTEL segmentation/normalization) and semi-automated regional parcellation, FreeSurfer (FS 4.3.1/64 bit). 3T T1 MPRAGE images were acquired from 19 volunteers with schizophrenia (SZ), 16 with schizoaffective disorder (SAD), 17 with psychotic bipolar I disorder (BD-P) and 10 healthy controls (HC). Contrasted with HC, SZ showed extensive cortical GM reductions, most pronounced in fronto-temporal regions; SAD had GM reductions overlapping with SZ, albeit less extensive; and BD-P demonstrated no GM differences from HC. Within the psychosis dimension, BD-P showed larger volumes in fronto-temporal and other cortical/subcortical regions compared with SZ, whereas SAD showed intermediate GM volumes. The two volumetric methodologies, VBM and FS, revealed highly overlapping results for cortical GM, but partially divergent results for subcortical volumes (basal ganglia, amygdala). Overall, these findings suggest that individuals across the psychosis dimension show both overlapping and unique GM phenotypes: decreased GM, predominantly in fronto-temporal regions, is characteristic of SZ but not of psychotic BD-P, whereas SAD display GM deficits overlapping with SZ, albeit less extensive.

Original languageEnglish (US)
Pages (from-to)13-24
Number of pages12
JournalPsychiatry Research - Neuroimaging
Volume204
Issue number1
DOIs
StatePublished - Oct 30 2012

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Psychotic Disorders
Phenotype
Schizophrenia
Brain
Temporal Lobe
Bipolar Disorder
Gray Matter
Amygdala
Basal Ganglia
Volunteers

Keywords

  • Bipolar disorder
  • FreeSurfer
  • Psychosis
  • Schizophrenia
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

Cite this

Brain gray matter phenotypes across the psychosis dimension. / Ivleva, Elena I.; Bidesi, Anup S.; Thomas, Binu P.; Meda, Shashwath A.; Francis, Alan; Moates, Amanda F.; Witte, Bradley; Keshavan, Matcheri S.; Tamminga, Carol A.

In: Psychiatry Research - Neuroimaging, Vol. 204, No. 1, 30.10.2012, p. 13-24.

Research output: Contribution to journalArticle

Ivleva, EI, Bidesi, AS, Thomas, BP, Meda, SA, Francis, A, Moates, AF, Witte, B, Keshavan, MS & Tamminga, CA 2012, 'Brain gray matter phenotypes across the psychosis dimension', Psychiatry Research - Neuroimaging, vol. 204, no. 1, pp. 13-24. https://doi.org/10.1016/j.pscychresns.2012.05.001
Ivleva, Elena I. ; Bidesi, Anup S. ; Thomas, Binu P. ; Meda, Shashwath A. ; Francis, Alan ; Moates, Amanda F. ; Witte, Bradley ; Keshavan, Matcheri S. ; Tamminga, Carol A. / Brain gray matter phenotypes across the psychosis dimension. In: Psychiatry Research - Neuroimaging. 2012 ; Vol. 204, No. 1. pp. 13-24.
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