Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

W. S.T. Griffin, L. C. Stanley, C. Ling, L. White, V. MacLeod, L. J. Perrot, C. L. White, C. Araoz

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Abstract

Interleukin 1, an immune response-generated cytokine that stimulates astrocyte proliferation and reactivity (astrogliosis), was presented in up to 30 times as many glial cells in tissue sections of brain from patients with Down syndrome and Alzheimer disease compared with age-matched control subjects. Most interleukin 1-immunoreactive glia in Down syndrome and Alzheimer disease were classified as microglia. The number of interleukin 1 immunoreactive neurons did not appear to differ in Down syndrome and Alzheimer disease compared with control brain. Numerous temporal lobe astrocytes in Alzheimer disease and postnatal Down syndrome were intensely interleukin 1-, S-100-, and glial fibrillary acidic protein-immunoreactive and had reactive structure. Interleukin 1 levels in Alzheimer disease temporal lobe homogenates were elevated, as were the levels of S-100 and glial fibrillary acidic protein, two proteins reportedly elevated in reactive astrocytes. These data suggest that increased expression of S-100 in Down syndrome, resulting from duplication of the gene on chromosome 21 that encodes the β subunit of S-100 may be augmented by elevation of interleukin 1. As a corollary, the astrogliosis in Alzheimer disease may be promoted by elevation of interleukin 1.

Original languageEnglish (US)
Pages (from-to)7611-7615
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume86
Issue number19
DOIs
StatePublished - Jan 1 1989

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Down Syndrome
Interleukin-1
Alzheimer Disease
Brain
Astrocytes
Glial Fibrillary Acidic Protein
Temporal Lobe
Neuroglia
Chromosomes, Human, Pair 21
Gene Duplication
Microglia
Cytokines
Neurons
Proteins

ASJC Scopus subject areas

  • General

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Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. / Griffin, W. S.T.; Stanley, L. C.; Ling, C.; White, L.; MacLeod, V.; Perrot, L. J.; White, C. L.; Araoz, C.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, No. 19, 01.01.1989, p. 7611-7615.

Research output: Contribution to journalArticle

Griffin, W. S.T. ; Stanley, L. C. ; Ling, C. ; White, L. ; MacLeod, V. ; Perrot, L. J. ; White, C. L. ; Araoz, C. / Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. In: Proceedings of the National Academy of Sciences of the United States of America. 1989 ; Vol. 86, No. 19. pp. 7611-7615.
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