Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial

Michael Grundman, Drahomira Sencakova, Clifford R. Jack, Ronald C. Petersen, Hyun T. Kim, Arlan Schultz, Myron F. Weiner, Charles DeCarli, Steven T. DeKosky, Christopher Van Dyck, Ronald G. Thomas, Leon J. Thal

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Mild Cognitive Impairment (MCI) is considered a transitional stage in the pathogenesis of Alzheimer's disease; however, not all MCI patients progress to clinically defined AD or decline at identical rates. Hippocampal atrophy, as measured by Magnetic Resonance Imaging (MRI), may be a marker for hippocampal pathology in patients with MCI and predict a more rapid deterioration to clinical AD. In this study, we used MRI data from an ongoing MCI clinical trial to determine whether MRI hippocampal volume at baseline was associated with cognitive and functional performance in MCI subjects and whether it predicted those individuals who were more likely to develop AD. We performed correlational analyses between the MRI hippocampal volumes at study entry and the subjects' concurrent performance on neuropsychological measures and clinical ratings. Larger hippocampal volume was associated with better performance on tests of memory, general cognition, and overall clinical ratings. Further analyses suggested that a smaller baseline hippocampal volume may be associated with a higher risk of developing clinical AD. As the trial is still ongoing, these results require confirmation once the trial is completed. In summary, these data suggest that MRI hippocampal volume may be a useful correlate of disease severity in MCI subjects and a prognostic indicator of subsequent AD.

Original languageEnglish (US)
Pages (from-to)23-27
Number of pages5
JournalJournal of Molecular Neuroscience
Volume19
Issue number1-2
StatePublished - Aug 2002

Fingerprint

Brain
Magnetic Resonance Imaging
Pathology
Deterioration
Cognition
Atrophy
Cognitive Dysfunction
Alzheimer Disease
Data storage equipment
Clinical Trials

Keywords

  • Alzheimer's disease
  • Clinical trial
  • Hippocampal volume
  • Mild Cognitive Impairment
  • MRI

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry
  • Genetics

Cite this

Grundman, M., Sencakova, D., Jack, C. R., Petersen, R. C., Kim, H. T., Schultz, A., ... Thal, L. J. (2002). Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial. Journal of Molecular Neuroscience, 19(1-2), 23-27.

Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial. / Grundman, Michael; Sencakova, Drahomira; Jack, Clifford R.; Petersen, Ronald C.; Kim, Hyun T.; Schultz, Arlan; Weiner, Myron F.; DeCarli, Charles; DeKosky, Steven T.; Van Dyck, Christopher; Thomas, Ronald G.; Thal, Leon J.

In: Journal of Molecular Neuroscience, Vol. 19, No. 1-2, 08.2002, p. 23-27.

Research output: Contribution to journalArticle

Grundman, M, Sencakova, D, Jack, CR, Petersen, RC, Kim, HT, Schultz, A, Weiner, MF, DeCarli, C, DeKosky, ST, Van Dyck, C, Thomas, RG & Thal, LJ 2002, 'Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial', Journal of Molecular Neuroscience, vol. 19, no. 1-2, pp. 23-27.
Grundman M, Sencakova D, Jack CR, Petersen RC, Kim HT, Schultz A et al. Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial. Journal of Molecular Neuroscience. 2002 Aug;19(1-2):23-27.
Grundman, Michael ; Sencakova, Drahomira ; Jack, Clifford R. ; Petersen, Ronald C. ; Kim, Hyun T. ; Schultz, Arlan ; Weiner, Myron F. ; DeCarli, Charles ; DeKosky, Steven T. ; Van Dyck, Christopher ; Thomas, Ronald G. ; Thal, Leon J. / Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial. In: Journal of Molecular Neuroscience. 2002 ; Vol. 19, No. 1-2. pp. 23-27.
@article{3eb2b3b1520044968843bed89a348fee,
title = "Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial",
abstract = "Mild Cognitive Impairment (MCI) is considered a transitional stage in the pathogenesis of Alzheimer's disease; however, not all MCI patients progress to clinically defined AD or decline at identical rates. Hippocampal atrophy, as measured by Magnetic Resonance Imaging (MRI), may be a marker for hippocampal pathology in patients with MCI and predict a more rapid deterioration to clinical AD. In this study, we used MRI data from an ongoing MCI clinical trial to determine whether MRI hippocampal volume at baseline was associated with cognitive and functional performance in MCI subjects and whether it predicted those individuals who were more likely to develop AD. We performed correlational analyses between the MRI hippocampal volumes at study entry and the subjects' concurrent performance on neuropsychological measures and clinical ratings. Larger hippocampal volume was associated with better performance on tests of memory, general cognition, and overall clinical ratings. Further analyses suggested that a smaller baseline hippocampal volume may be associated with a higher risk of developing clinical AD. As the trial is still ongoing, these results require confirmation once the trial is completed. In summary, these data suggest that MRI hippocampal volume may be a useful correlate of disease severity in MCI subjects and a prognostic indicator of subsequent AD.",
keywords = "Alzheimer's disease, Clinical trial, Hippocampal volume, Mild Cognitive Impairment, MRI",
author = "Michael Grundman and Drahomira Sencakova and Jack, {Clifford R.} and Petersen, {Ronald C.} and Kim, {Hyun T.} and Arlan Schultz and Weiner, {Myron F.} and Charles DeCarli and DeKosky, {Steven T.} and {Van Dyck}, Christopher and Thomas, {Ronald G.} and Thal, {Leon J.}",
year = "2002",
month = "8",
language = "English (US)",
volume = "19",
pages = "23--27",
journal = "Journal of Molecular Neuroscience",
issn = "0895-8696",
publisher = "Humana Press",
number = "1-2",

}

TY - JOUR

T1 - Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial

AU - Grundman, Michael

AU - Sencakova, Drahomira

AU - Jack, Clifford R.

AU - Petersen, Ronald C.

AU - Kim, Hyun T.

AU - Schultz, Arlan

AU - Weiner, Myron F.

AU - DeCarli, Charles

AU - DeKosky, Steven T.

AU - Van Dyck, Christopher

AU - Thomas, Ronald G.

AU - Thal, Leon J.

PY - 2002/8

Y1 - 2002/8

N2 - Mild Cognitive Impairment (MCI) is considered a transitional stage in the pathogenesis of Alzheimer's disease; however, not all MCI patients progress to clinically defined AD or decline at identical rates. Hippocampal atrophy, as measured by Magnetic Resonance Imaging (MRI), may be a marker for hippocampal pathology in patients with MCI and predict a more rapid deterioration to clinical AD. In this study, we used MRI data from an ongoing MCI clinical trial to determine whether MRI hippocampal volume at baseline was associated with cognitive and functional performance in MCI subjects and whether it predicted those individuals who were more likely to develop AD. We performed correlational analyses between the MRI hippocampal volumes at study entry and the subjects' concurrent performance on neuropsychological measures and clinical ratings. Larger hippocampal volume was associated with better performance on tests of memory, general cognition, and overall clinical ratings. Further analyses suggested that a smaller baseline hippocampal volume may be associated with a higher risk of developing clinical AD. As the trial is still ongoing, these results require confirmation once the trial is completed. In summary, these data suggest that MRI hippocampal volume may be a useful correlate of disease severity in MCI subjects and a prognostic indicator of subsequent AD.

AB - Mild Cognitive Impairment (MCI) is considered a transitional stage in the pathogenesis of Alzheimer's disease; however, not all MCI patients progress to clinically defined AD or decline at identical rates. Hippocampal atrophy, as measured by Magnetic Resonance Imaging (MRI), may be a marker for hippocampal pathology in patients with MCI and predict a more rapid deterioration to clinical AD. In this study, we used MRI data from an ongoing MCI clinical trial to determine whether MRI hippocampal volume at baseline was associated with cognitive and functional performance in MCI subjects and whether it predicted those individuals who were more likely to develop AD. We performed correlational analyses between the MRI hippocampal volumes at study entry and the subjects' concurrent performance on neuropsychological measures and clinical ratings. Larger hippocampal volume was associated with better performance on tests of memory, general cognition, and overall clinical ratings. Further analyses suggested that a smaller baseline hippocampal volume may be associated with a higher risk of developing clinical AD. As the trial is still ongoing, these results require confirmation once the trial is completed. In summary, these data suggest that MRI hippocampal volume may be a useful correlate of disease severity in MCI subjects and a prognostic indicator of subsequent AD.

KW - Alzheimer's disease

KW - Clinical trial

KW - Hippocampal volume

KW - Mild Cognitive Impairment

KW - MRI

UR - http://www.scopus.com/inward/record.url?scp=0036672710&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036672710&partnerID=8YFLogxK

M3 - Article

C2 - 12212787

AN - SCOPUS:0036672710

VL - 19

SP - 23

EP - 27

JO - Journal of Molecular Neuroscience

JF - Journal of Molecular Neuroscience

SN - 0895-8696

IS - 1-2

ER -